Lysophospholipid receptors: signaling and biology
▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors
MJ Kluk, T Hla - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2002 - Elsevier
The sphingosine-1-phosphate/Endothelial Differentiation Gene (S1P/EDG) family of G-
protein-coupled receptors (GPCR) currently includes five different isoforms, which …
protein-coupled receptors (GPCR) currently includes five different isoforms, which …
Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors
H Ohta, K Sato, N Murata, A Damirin… - Molecular …, 2003 - ASPET
Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific
receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly …
receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly …
Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LPB3/EDG-3
I Ishii, B Friedman, X Ye, S Kawamura… - Journal of Biological …, 2001 - ASBMB
Sphingosine 1-phosphate (S1P) exerts diverse physiological actions by activating its
cognate G protein-coupled receptors. Five S1P receptors have been identified in mammals …
cognate G protein-coupled receptors. Five S1P receptors have been identified in mammals …
Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?
F Okajima - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2002 - Elsevier
Sphingosine 1-phosphate (S1P) concentration in plasma and serum has been estimated to
be within 200–900 nM. Among plasma and serum components, S1P is concentrated in …
be within 200–900 nM. Among plasma and serum components, S1P is concentrated in …
Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells
T Kimura, K Sato, A Kuwabara, H Tomura… - Journal of Biological …, 2001 - ASBMB
Sphingosine 1-phosphate (S1P), a novel lipid mediator, is concentrated in the fraction of
lipoproteins that include high density lipoprotein (HDL) and low density lipoprotein (LDL) in …
lipoproteins that include high density lipoprotein (HDL) and low density lipoprotein (LDL) in …
Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3
I Ishii, X Ye, B Friedman, S Kawamura… - Journal of Biological …, 2002 - ASBMB
Five cognate G protein-coupled receptors (S1P 1–5) have been shown to mediate various
cellular effects of sphingosine 1-phosphate (S1P). Here we report the generation of mice …
cellular effects of sphingosine 1-phosphate (S1P). Here we report the generation of mice …
Dendritic cell migration to lymph nodes: cytokines, chemokines, and lipid mediators
GJ Randolph - Seminars in immunology, 2001 - Elsevier
Mobilization of dendritic cells into lymphatic vessels requires cytokine stimulation and
induction of the chemokine receptor CCR7. The respective roles of the CCR7 ligands …
induction of the chemokine receptor CCR7. The respective roles of the CCR7 ligands …
Athero-and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate
W Siess - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2002 - Elsevier
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are potent bioactive
phospholipids with specific and multiple effects on blood cells and cells of the vessel wall …
phospholipids with specific and multiple effects on blood cells and cells of the vessel wall …
Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy
TA Taha, KM Argraves, LM Obeid - … et Biophysica Acta (BBA)-Molecular and …, 2004 - Elsevier
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that has recently been shown to
bind cell surface S1P receptors (previously called endothelial differentiation gene (Edg) …
bind cell surface S1P receptors (previously called endothelial differentiation gene (Edg) …