The 26S proteasome: a molecular machine designed for controlled proteolysis
D Voges, P Zwickl, W Baumeister - Annual review of …, 1999 - annualreviews.org
▪ Abstract In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the
ubiquitin-proteasome pathway. The 26S proteasome is a 2.5-MDa molecular machine built …
ubiquitin-proteasome pathway. The 26S proteasome is a 2.5-MDa molecular machine built …
[HTML][HTML] The proteasome: paradigm of a self-compartmentalizing protease
W Baumeister, J Walz, F Zühl, E Seemüller - Cell, 1998 - cell.com
Protein degradation is a necessity for many reasons: Homeostasis must be maintained while
cellular structures are continually rebuilt, in particular during development or in response to …
cellular structures are continually rebuilt, in particular during development or in response to …
Molecular mechanisms of proteasome assembly
The 26S proteasome is a highly conserved protein degradation machine that consists of the
20S proteasome and 19S regulatory particles, which include 14 and 19 different …
20S proteasome and 19S regulatory particles, which include 14 and 19 different …
The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes: implications for understanding the degradative mechanism and antigen …
AF Kisselev, TN Akopian, KM Woo… - Journal of Biological …, 1999 - ASBMB
Knowledge about the sizes of peptides generated by proteasomes during protein
degradation is essential to fully understand their degradative mechanisms and the …
degradation is essential to fully understand their degradative mechanisms and the …
Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis
The protein modifier ubiquitin is a signal for proteasome-mediated degradation in
eukaryotes. Proteasome-bearing prokaryotes have been thought to degrade proteins via a …
eukaryotes. Proteasome-bearing prokaryotes have been thought to degrade proteins via a …
Targeted protein degradation: advances, challenges, and prospects for computational methods
The therapeutic approach of targeted protein degradation (TPD) is gaining momentum due
to its potentially superior effects compared with protein inhibition. Recent advancements in …
to its potentially superior effects compared with protein inhibition. Recent advancements in …
The proteasome
M Bochtler, L Ditzel, M Groll… - Annual review of …, 1999 - annualreviews.org
▪ Abstract Proteasomes are large multisubunit proteases that are found in the cytosol, both
free and attached to the endoplasmic reticulum, and in the nucleus of eukaryotic cells. Their …
free and attached to the endoplasmic reticulum, and in the nucleus of eukaryotic cells. Their …
Proteolysis in plants: mechanisms and functions
RD Vierstra - Post-Transcriptional Control of Gene Expression in …, 1996 - Springer
Proteolysis is essential for many aspects of plant physiology and development. It is
responsible for cellular housekeeping and the stress response by removing …
responsible for cellular housekeeping and the stress response by removing …
Catalytic activities of the 20 S proteasome, a multicatalytic proteinase complex
M Orlowski, S Wilk - Archives of biochemistry and biophysics, 2000 - Elsevier
The proteasome, a multisubunit, multicatalytic proteinase complex, is attracting growing
attention as the main intracellular, extralysosomal, proteolytic system involved in ubiquitin …
attention as the main intracellular, extralysosomal, proteolytic system involved in ubiquitin …
Differential ligand‐dependent interactions between the AF‐2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and …
E Vom Baur, C Zechel, D Heery, MJ Heine… - The EMBO …, 1996 - embopress.org
Using a yeast two‐hybrid system we report the isolation of a novel mouse protein, mSUG1,
that interacts with retinoic acid receptor alpha (RAR alpha) both in yeast cells and in vitro in …
that interacts with retinoic acid receptor alpha (RAR alpha) both in yeast cells and in vitro in …