Recent evidence from omic analysis for redox signalling and mitochondrial oxidative stress in COPD
COPD is driven by exogenous and endogenous oxidative stress derived from inhaled
cigarette smoke, air pollution and reactive oxygen species from dysregulated mitochondria …
cigarette smoke, air pollution and reactive oxygen species from dysregulated mitochondria …
Senescence: pathogenic driver in chronic obstructive pulmonary disease
M Rivas, G Gupta, L Costanzo, H Ahmed, AE Wyman… - Medicina, 2022 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is recognized as a disease of accelerated
lung aging. Over the past two decades, mounting evidence suggests an accumulation of …
lung aging. Over the past two decades, mounting evidence suggests an accumulation of …
The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi
LLY Chan, DE Anderson, HS Cheng, FX Ivan… - Nature …, 2022 - nature.com
Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation and
infective exacerbations, however, in-vitro model systems for the study of host-pathogen …
infective exacerbations, however, in-vitro model systems for the study of host-pathogen …
[HTML][HTML] Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease
Systemic inflammation is established as part of late-stage severe lung disease, but
molecular, functional, and phenotypic changes in peripheral immune cells in early disease …
molecular, functional, and phenotypic changes in peripheral immune cells in early disease …
Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis
Tobacco smoking doubles the risk of active tuberculosis (TB) and accounts for up to 20% of
all active TB cases globally. How smoking promotes lung microenvironments permissive to …
all active TB cases globally. How smoking promotes lung microenvironments permissive to …
Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease
P Liu, Y Wang, N Zhang, X Zhao, R Li, Y Wang… - Respiratory …, 2022 - Springer
Background Chronic obstructive pulmonary disease (COPD) is one of the world's leading
causes of death and a major chronic disease, highly prevalent in the aging population …
causes of death and a major chronic disease, highly prevalent in the aging population …
Accelerated epigenetic age, inflammation, and gene expression in lung: comparisons of smokers and vapers with non-smokers
MA Song, KM Mori, JP McElroy, JL Freudenheim… - Clinical …, 2023 - Springer
Background Cigarette smoking and aging are the main risk factors for pulmonary diseases,
including cancer. Epigenetic aging may explain the relationship between smoking …
including cancer. Epigenetic aging may explain the relationship between smoking …
Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
AJ Ghosh, BD Hobbs, JH Yun, A Saferali, M Moll… - Respiratory …, 2022 - Springer
Background Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary
fibrosis (IPF) are characterized by shared exposures and clinical features, but distinct …
fibrosis (IPF) are characterized by shared exposures and clinical features, but distinct …
Single cell RNA sequencing identifies IGFBP5 and QKI as ciliated epithelial cell genes associated with severe COPD
X Li, G Noell, T Tabib, AD Gregory, HE Trejo Bittar… - Respiratory …, 2021 - Springer
Background Whole lung tissue transcriptomic profiling studies in chronic obstructive
pulmonary disease (COPD) have led to the identification of several genes associated with …
pulmonary disease (COPD) have led to the identification of several genes associated with …
The role of ferroptosis in bronchoalveolar epithelial cell injury induced by cigarette smoke extract
N Lian, Q Zhang, J Chen, M Chen, J Huang… - Frontiers in …, 2021 - frontiersin.org
Background: Cigarette smoking is a major risk factor for bronchoalveolar epithelial cell
(BAEC) injury. Understanding the relevant pathogenesis is important for the treatment of …
(BAEC) injury. Understanding the relevant pathogenesis is important for the treatment of …