Neuropilin-1 and Neuropilin-2 form a small family of plasma membrane spanning receptors
originally identified by the binding of semaphorin and vascular endothelial growth factor …

Abstract Neuropilin-1 and neuropilin-2 form a small family of transmembrane receptors,
which, due to the lack of a cytosolic protein kinase domain, act primarily as co-receptors for …

Abstract Development of antagonistic antibody (Ab) against interleukin-4 receptor alpha (IL-
4Rα) subunit of IL-4/IL-13 receptors is a promising therapeutic strategy for T helper 2 (TH2) …

Immunotoxins (ITs), which are toxin-fused tumor antigen-specific antibody chimeric proteins,
have been developed to selectively kill targeted cancer cells. The epidermal growth factor …

Given the previous SARS-CoV-2 pandemic and the inherent unpredictability of viral
antigenic drift and shift, preemptive development of diverse neutralizing antibodies targeting …

Aims This study aimed to design and screen a dual functional fusion peptide that could
penetrate the blood-brain barrier and target neuropilin 1 (NRP1) overexpressed in vascular …

Fusion of a target-specific peptide to a full-length antibody (Ab) can result in a peptide–Ab
fusion protein with additional specificity and enhanced activity. We recently developed an …

The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health concern. It is now well …

Ubiquitination is the covalent attachment of ubiquitin (Ub) to substrate proteins and
regulates several cellular processes, including protein degradation. Ub ligases (E3s) bring a …

Yeast surface display (YSD) is a powerful methodology for discovery and engineering of
antibodies, and the yeast mating has been used to overcome low transformation efficiency of …