As important genome editing tools, CRISPR/Cas systems, especially those based on type II
Cas9 and type V Cas12a, are widely used in genetic and metabolic engineering of bacteria …

The Actinomycetales order is one of great genetic and functional diversity, including diversity
in the production of secondary metabolites which have uses in medical, environmental …

Throughout the golden age of antibiotic discovery, Streptomyces have been unsurpassed for
their ability to produce bioactive metabolites. Yet, this success has been hampered by …

Throughout the decades of its history, the advances in bacteria-based bio-industries have
coincided with great leaps in strain engineering technologies. Recently unveiled clustered …

Covering: up to February, 2018 This review briefly introduces and summarizes current
knowledge about the Clustered Regularly Interspaced Short Palindromic Repeats …

Covering: up to December 2018 This article aims to highlight advantages, drawbacks and
issues that users should consider when implementing the use of CRISPR/Cas9-tools for …

Antimicrobial resistance (AMR) poses a significant threat to the health, social, environment,
and economic sectors on a global scale and requires serious attention to addressing this …

Microbial natural products (NPs) especially of the Streptomyces genus have been regarded
as an unparalleled resource for pharmaceutical drugs discovery. Moreover, recent progress …

Natural products and their related derivatives play a significant role in drug discovery and
have been the inspiration for the design of numerous synthetic bioactive compounds. With …

微生物合成生物学是一门新兴的交叉学科, 其主要目的是通过改造或创制微生物细胞,
使微生物具有特定的生理功能或生产目标产物, 因此需要高效, 快速, 精准的基因操作工具 …