Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study

YL Wu, ZJ Lin, CC Li, X Lin, SK Shan, B Guo… - … and Targeted Therapy, 2023 - nature.com
Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

[HTML][HTML] MicroRNAs in autoimmune thyroid diseases and their role as biomarkers

R Martínez-Hernández, M Marazuela - Best Practice & Research Clinical …, 2023 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the
posttranscriptional level. They are emerging as potential biomarkers and as therapeutic …

The role of thyroid hormone in the renal immune microenvironment

Z Han, L Chen, H Peng, H Zheng, Y Lin, F Peng… - International …, 2023 - Elsevier
Thyroid hormones are essential for proper kidney growth and development. The kidney is
not only the organ of thyroid hormone metabolism but also the target organ of thyroid …

Decreased expression of miR-29 family associated with autoimmune myasthenia gravis

MA Cron, CA Payet, OM Fayet, S Maillard… - Journal of …, 2020 - Springer
Background Myasthenia gravis (MG) is a rare autoimmune disease mainly mediated by
autoantibodies against the acetylcholine receptor (AChR) at the neuromuscular junction …

Emerging roles for noncoding RNAs in autoimmune thyroid disease

L Yin, C Zeng, J Yao, J Shen - Endocrinology, 2020 - academic.oup.com
Autoimmune thyroid disease (AITD) is one of the most frequent autoimmune disorders.
However, the pathogenesis of AITD has not been fully elucidated. Recently, accumulating …

DNA hypermethylation of PTPN22 gene promoter in children and adolescents with Hashimoto thyroiditis

I Kyrgios, S Giza, A Fragou, G Tzimagiorgis… - Journal of …, 2021 - Springer
Purpose Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is an inhibitor of T-
cell activation, regulating intracellular signal transduction and thereby being implicated in …

Nonspecific Orbital Inflammation (NSOI): Unraveling the Molecular Pathogenesis, Diagnostic Modalities, and Therapeutic Interventions

KY Wu, M Kulbay, P Daigle, BH Nguyen… - International Journal of …, 2024 - mdpi.com
Nonspecific orbital inflammation (NSOI), colloquially known as orbital pseudotumor,
sometimes presents a diagnostic and therapeutic challenge in ophthalmology. This review …

A systematic review of dysregulated microRNAs in Hashimoto's thyroiditis

A Zadeh-Vakili, B Faam, A Afgar, E Razmpoosh… - Endocrine, 2024 - Springer
Background Plenty of evidence suggests that dysregulated microRNAs are linked to
developing autoimmune thyroid diseases. In this study, we aimed to identify commonly …

Identification of miR-29a as a novel biomarker for lumpy skin disease virus exposure in cattle

R Kumar, H Kamboj, S Dhanda, A Verma, Y Chander… - Virulence, 2024 - Taylor & Francis
Micro RNAs (miRNAs) have been implicated in the regulation of maturation, proliferation,
differentiation, and activation of immune cells. In this study, we demonstrated that miR-29a …

HDAC6-specific inhibitor alleviates hashimoto's thyroiditis through inhibition of Th17 cell differentiation

Q Chang, D Yin, H Li, X Du, Z Wang, Y Liu… - Molecular Immunology, 2022 - Elsevier
Objective Hashimoto's thyroiditis (HT) is one of the commonest autoimmune disorders. This
study was performed to investigate the potential effect of histone deacetylase 6-specific …