Colorectal cancer (CRC) ranks third among the most commonly occurring cancers
worldwide, and it causes half a million deaths annually. Alongside mechanistic study for …

The human genome contains more than 200,000 gene isoforms. However, different isoforms
can be highly similar, and with an average length of 1.5 kb remain difficult to study with short …

Adaptin proteins (APs) play a crucial role in intracellular cell trafficking. The 'classical'role of
APs is carried out by AP1‒3, which bind to clathrin, cargo, and accessory proteins …

In cancer, fusions are important diagnostic markers and targets for therapy. Long-read
transcriptome sequencing allows the discovery of fusions with their full-length isoform …

In contrast to many other sarcoma subtypes, the chaotic karyotypes of osteosarcoma have
precluded the identification of pathognomonic translocations. We here report hundreds of …

Almost all deaths from breast cancer arise from metastasis of the transformed cells to other
sites in the body. Hence, uncovering a means of inhibiting breast cancer cell migration …

Context Pathogenesis of autonomous steroid secretion and adrenocortical tumorigenesis
remains partially obscure. Objective To investigate the relationship between transcriptome …

Gene fusions that contribute to oncogenicity can be explored for identifying cancer
biomarkers and potential drug targets. To investigate the nature and distribution of fusion …

Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality
worldwide. Currently, there is limited knowledge of dysregulation of cellular proliferation and …

Many human genes are transcribed from both strands and produce sense-antisense gene
pairs. Sense-antisense (SAS) chimeric transcripts are produced upon the coalescing of …