Overview on neural tube defects: From development to physical characteristics

L Avagliano, V Massa, TM George… - Birth defects …, 2019 - Wiley Online Library
Neural tube defects (NTDs) are the second most common congenital malformations in
humans affecting the development of the central nervous system. Although NTD …

Gene environment interactions in the etiology of neural tube defects

RH Finnell, CD Caiaffa, SE Kim, Y Lei, J Steele… - Frontiers in …, 2021 - frontiersin.org
Human structural congenital malformations are the leading cause of infant mortality in the
United States. Estimates from the United States Center for Disease Control and Prevention …

[HTML][HTML] Essential trace elements in placental tissue and risk for fetal neural tube defects

S Yin, C Wang, J Wei, D Wang, L Jin, J Liu… - Environment …, 2020 - Elsevier
This study examined the associations between concentrations of cobalt (Co), iron (Fe),
manganese (Mn), molybdenum (Mo), selenium (Se), and zinc (Zn) in placental tissue and …

Formate rescues neural tube defects caused by mutations in Slc25a32

J Kim, Y Lei, J Guo, SE Kim… - Proceedings of the …, 2018 - National Acad Sciences
Periconceptional folic acid (FA) supplementation significantly reduces the prevalence of
neural tube defects (NTDs). Unfortunately, some NTDs are FA resistant, and as such, NTDs …

Single and mixed effects of metallic elements in maternal serum during pregnancy on risk for fetal neural tube defects: A Bayesian kernel regression approach

T Tian, S Yin, L Jin, J Liu, C Wang, J Wei, M Liu… - Environmental …, 2021 - Elsevier
Studies of the association between prenatal exposure to metal elements and risk for neural
tube defects (NTDs) have produced inconsistent results. Little research has examined the …

Folate fortification and supplementation in prevention of folate-sensitive neural tube defects: a systematic review of policy

NA Shlobin, MA LoPresti, RY Du, S Lam - Journal of Neurosurgery …, 2020 - thejns.org
OBJECTIVE Neural tube defects (NTDs) are common congenital neurological defects,
resulting in mortality, morbidity, and impaired quality of life for patients and caregivers. While …

[HTML][HTML] Organoids as a new model system to study neural tube defects

Y Wu, S Peng, RH Finnell, Y Zheng - FASEB journal: official …, 2021 - ncbi.nlm.nih.gov
The neural tube is the first critically important structure that develops in the embryo. It serves
as the primordium of the central nervous system; therefore, the proper formation of the …

Digenic variants of planar cell polarity genes in human neural tube defect patients

L Wang, Y Xiao, T Tian, L Jin, Y Lei, RH Finnell… - Molecular genetics and …, 2018 - Elsevier
Neural tube defects (NTDs) are considered to be a complex genetic disorder, although the
identity of the genetic factors remains largely unknown. Mouse model studies suggest a …

Association of assisted reproductive technology and multiple pregnancies with the risks of birth defects and stillbirth: a retrospective cohort study

M Yang, XB Fan, JN Wu, JM Wang - Scientific reports, 2018 - nature.com
Assisted reproductive technology (ART) has been widely used among women with infertility.
However, the association of ART with birth defects and stillbirth remains controversial and …

Associations between prenatal exposure to cadmium and lead with neural tube defect risks are modified by single-nucleotide polymorphisms of fetal MTHFR and …

M Liu, J Yu, Z Su, Y Sun, Y Liu, Q Xie, Z Li, L Wang… - Environmental …, 2021 - Springer
Background Prenatal exposure to heavy metals is implicated in the etiology of birth defects.
We investigated whether concentrations of cadmium (Cd) and lead (Pb) in umbilical cord …