Bioprinting techniques have been flourishing in the field of biofabrication with pronounced
and exponential developments in the past years. Novel biomaterial inks used for the …

The response of immune cells in cardiac injury is divided into three continuous phases:
inflammation, proliferation and maturation. The kinetics of the inflammatory and proliferation …

Background: In addition to scalability, human embryonic stem cells (hESCs) have the unique
advantage of allowing their directed differentiation toward lineage-specific cells. Objectives …

Circulation. 2017; 136: 680–686. DOI: 10.1161/CIRCULATIONAHA. 117.029343 August 15,
2017 681 proliferation. 5 It remains unclear whether this regenerative window exists in large …

Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …

An in vitro model of the human kidney glomerulus—the major site of blood filtration—could
facilitate drug discovery and illuminate kidney-disease mechanisms. Microfluidic organ-on-a …

Aims Comparative studies suggest that stem cells committed to a cardiac lineage are more
effective for improving heart function than those featuring an extra-cardiac phenotype. We …

Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …

Rationale: More than 25 million individuals have heart failure worldwide, with≈ 4000
patients currently awaiting heart transplantation in the United States. Donor organ shortage …

Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …