Natural products are an important source of new drugs for the treatment of various diseases.
However, developing natural product-based new medicines through random moiety …

Artemisinin is the crucial ingredient of artemisia annua, a traditional Chinese medicine used
for the therapy of malaria in China for hundreds of years. In recent years, the anticancer …

In recent years, biologically active natural products have gradually become important agents
in the field of drug research and development because of their wide availability and variety …

The discovery of drugs from marine natural products has witnessed a significant resurgence
in recent years. A diverse range of marine organisms, including cone snails, bacteria …

Peptide interactions with lipid bilayers play a key role in a range of biological processes and
depend on electrostatic interactions between charged amino acids and lipid headgroups …

绿色新农药的开发和利用有利于农业的可持续发展, 基于天然产物进行活性先导发现及作用机制
研究是重要的新农药创制策略, 然而其作用靶标和作用机制难以确定, 阻碍了其在新农药中的 …

Acinetobacter baumannii, has been developing resistance to even the last line of drugs.
Antimicrobial peptides (AMPs) to which bacteria do not develop resistance easily may be the …

In this dissertation the mechanistic causes of the adverse effects of marketed
fluoroquinolone antibiotics in human cells were studied by the elucidation of protein off …

Antimicrobial peptides (AMPs) initiate killing of bacteria by binding to and destabilizing their
membranes. The multiple peptide resistance factor (MprF) provides a defence mechanism …