It is established that a decrease in β‑cell number and deficiency in the function of existing β‑
cells contribute to type 1 and type 2 diabetes mellitus. Therefore, a major focus of current …

Pancreatic islet cells derived from human pluripotent stem cells hold great promise for
modeling and treating diabetes. Differences between stem-cell-derived and primary islets …

Diabetes is both a metabolic and an immune disorder. One intriguing link between the two is
the serine-threonine protein kinase mammalian target of rapamycin (mTOR). As a …

Prolonged exercise has positive metabolic effects in obese or diabetic individuals. These
effects are usually ascribed to improvements in insulin sensitivity. We evaluated whether …

Objectives Signal transducer and activator of transcription 3 (STAT3) is constitutively
activated and overexpressed in many cancers, including non–small‐cell lung cancer …

Insufficient pancreatic β-cell mass and reduced insulin expression are key events in the
pathogenesis of diabetes mellitus (DM). Here we demonstrate the high expression of Talin-1 …

Insufficient pancreatic β-cell mass or insulin-producing β-cells are implicated in all forms of
diabetes mellitus. However, the molecular mechanisms underlying β-cell destruction are …

Endogenous humoral factors that link systemic and/or local insulin demand to pancreatic β-
cells have not been identified. Here, we demonstrated that T-cadherin, a unique …

Pancreatic islet cells derived from human pluripotent stem cells hold great promise for
modeling and treating diabetes. Differences between stem cell-derived and primary islets …

Islet transplantation (ITx) is an established and safe alternative to pancreas transplantation
for type 1 diabetes mellitus (T1DM) patients. However, most ITx recipients lose insulin …