Animal models of chronic obstructive pulmonary disease

S Pérez-Rial, Á Girón-Martínez… - Archivos de …, 2015 - Elsevier
Animal models of disease have always been welcomed by the scientific community because
they provide an approach to the investigation of certain aspects of the disease in question …

The therapeutic effects of optimal dose of mesenchymal stem cells in a murine model of an elastase induced-emphysema

YS Kim, JY Kim, JW Huh, SW Lee… - Tuberculosis and …, 2015 - synapse.koreamed.org
Background Chronic obstructive pulmonary disease is characterized by emphysema,
chronic bronchitis, and small airway remodeling. The alveolar destruction associated with …

Therapeutic effects of adipose-derived stem cells pretreated with pioglitazone in an emphysema mouse model

Y Hong, YS Kim, SH Hong, YM Oh - Experimental & Molecular Medicine, 2016 - nature.com
There is no therapy currently available that influences the natural history of disease
progression in patients with chronic obstructive pulmonary disease (COPD). Although stem …

Differential lung gene expression identified Zscan2 and Bag6 as novel tissue repair players in an experimental COPD model

L Sánchez Carretero, ÀC Cardeñosa Pérez… - Plos one, 2024 - journals.plos.org
Chronic obstructive pulmonary disease is a common chronic lung disease with an ever-
increasing incidence. Despite years of drug research and approvals, we are still not able to …

Potential therapeutic strategy in chronic obstructive pulmonary disease using pioglitazone-augmented Wharton's jelly-derived mesenchymal stem cells

JS Park, HK Kim, EY Kang, RJ Cho… - Tuberculosis and …, 2019 - synapse.koreamed.org
Background A recent study reported that mesenchymal stem cells possess potential cellular
therapeutic properties for treating patients with chronic obstructive pulmonary disease …

Effect of recombinant human keratinocyte growth factor in inducing Ras–Raf–Erk pathway-mediated cell proliferation in emphysematous mice lung

JP Muyal, S Kotnala, H Bhardwaj, A Tyagi - Inhalation Toxicology, 2014 - Taylor & Francis
Context: Pulmonary emphysema is resulted due to destruction of the structure of the alveoli.
Recently, exogenous recombinant human Keratinocyte growth factor (rHuKGF) has been …

Proliferative activity of liver growth factor is associated with an improvement of cigarette smoke-induced emphysema in mice

Á Girón-Martínez, S Perez-Rial, R Terron-Exposito… - PLoS …, 2014 - journals.plos.org
Cigarette smoke (CS)-induced emphysema is a major component of chronic obstructive
pulmonary disease (COPD). COPD treatment is based on the administration of …

IL-1β induces a proinflammatory fibroblast microenvironment that impairs lung progenitors' function

C Ciminieri, ME Woest, NL Reynaert… - American Journal of …, 2023 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is characterized by a persistent
inflammatory state in the lungs and defective tissue repair. Although the inflammatory …

Modelos animales de enfermedad pulmonar obstructiva crónica

S Pérez-Rial, Á Girón-Martínez… - Archivos de …, 2015 - Elsevier
El desarrollo de modelos animales de una enfermedad ha sido siempre bien acogido por la
comunidad científica porque permite realizar una aproximación a la investigación de …

Lung gene expression study identifying Zscan2 and Bag6 as novel tissue repair players in an experimental model of COPD

S Pérez-Rial, LS Carretero, ÀCC Pérez… - 2023 - researchsquare.com
Background Chronic obstructive pulmonary disease (COPD) is a common chronic lung
disease with an ever-increasing incidence. Despite years of drug research and approvals …