Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

The metabolic syndrome is an important public health concern that predisposes individuals
to the development of cardiovascular disease and/or Type 2 diabetes. The fructose-fed rat is …

Insulin increases glucose disposal into muscle. In addition, in vivo insulin elicits distinct nitric
oxide synthase-dependent vascular responses to increase total skeletal muscle blood flow …

Evidence suggests that insulin delivery to skeletal muscle interstitium is the rate-limiting step
in insulin-stimulated muscle glucose uptake and that this process is impaired by insulin …

The vascular system controls the delivery of nutrients and hormones to muscle, and a
number of hormones may act to regulate muscle metabolism and contractile performance by …

We examined the effects of inhibiting nitric oxide synthase with N ω-nitro-l-arginine-methyl
ester (l-NAME) on total hindlimb blood flow, muscle microvascular recruitment, and hindlimb …

Over the past 10 years it has become clear that intact vascular function, especially at the
level of the endothelium, is paramount in the prevention or delay of cardiovascular disease …

We have previously shown that skeletal muscle capillaries are rapidly recruited by
physiological doses of insulin in both humans and animals. This facilitates glucose and …

Obesity is an important risk factor for insulin resistance and hypertension and plays a central
role in the metabolic syndrome. Insight into the pathophysiology of this syndrome may lead …

Despite intensive study, the relation between insulin's action on blood flow and glucose
metabolism remains unclear. Insulin-induced changes in microvascular perfusion …