Energy metabolism and redox state are intrinsically linked. In order to mount an adequate
immune response, cells must have an adequate and rapidly available energy resource to …

The production of reactive oxygen species (ROS) within immune cell phagosomes is critical
for antimicrobial activity and for correct antigen processing, and influences signaling …

Macrophages respond to changes in environmental stimuli by assuming distinct functional
phenotypes, a phenomenon referred to as macrophage polarization. We generated …

The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …

Tissue engineering and regenerative medicine hold promise for improving or even restoring
the function of damaged organs. Graphene-based materials (GBMs) have become a key …

This review describes the complex interplay between inflammation, vasculopathy and
fibrosis that involve the heart and peripheral small vessels, leading to endothelial stiffness …

Dysfunction of phagocytes is a relevant risk factor for staphylococcal infection. The most
common hereditary phagocyte dysfunction is chronic granulomatous disease (CGD) …

Significance: The evolution of the lungs and circulatory systems in vertebrates ensured the
availability of molecular oxygen (O2; dioxygen) for aerobic cellular metabolism of internal …

Macrophages are capable of assuming distinct, meta-stable, functional phenotypes in
response to environmental cues—a process referred to as macrophage polarization. The …

Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease including the
cardiovascular system. Atherosclerosis is the most common cardiovascular complication of …