Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …

In recent years, the population of neurons in the ventral tegmental area (VTA) and substantia
nigra (SN) has been examined at multiple levels. The results indicate that the projections …

Electrical excitation of peripheral somatosensory nerves is a first step in generation of most
pain signals in mammalian nervous system. Such excitation is controlled by an intricate set …

The brain circuit projecting from the ventral tegmental area (VTA) to the nucleus accumbens
lateral shell (NAcLat) has a key role in methamphetamine (MA) addiction. As different …

Ion channel targeted drugs have always been related with either the central nervous system
(CNS), the peripheral nervous system, or the cardiovascular system. Within the CNS, basic …

Bone cancer pain has a strong impact on the quality of life of patients, but is difficult to treat.
Better understanding of the pathogenic mechanisms underlying bone cancer pain will likely …

Neuropathic pain is a severe health problem for which there is a lack of effective therapy. A
frequent underlying condition of neuropathic pain is a sustained overexcitability of pain …

Dopaminergic signaling in the nucleus accumbens shell (NAc) regulates neuronal activity
relevant to reward-related learning, including cocaine-associated behaviors. Although …

The gut-derived orexigenic peptide hormone ghrelin enhances neuronal firing in the
substantia nigra pars compacta, where dopaminergic neurons modulate the function of the …

Activity-dependent persistent changes in neuronal intrinsic excitability and synaptic strength
are widely thought to underlie learning and memory. Voltage-gated KCNQ/Kv7 potassium …