Targeting fibrosis: Mechanisms and clinical trials

M Zhao, L Wang, M Wang, S Zhou, Y Lu… - Signal transduction and …, 2022 - nature.com
Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

Idiopathic pulmonary fibrosis and lung cancer: mechanisms and molecular targets

B Ballester, J Milara, J Cortijo - International journal of molecular sciences, 2019 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary
disease with a median survival of 2–4 years after diagnosis. A significant number of IPF …

Progressive pulmonary fibrosis: an expert group consensus statement

SK Rajan, V Cottin, R Dhar, S Danoff… - European …, 2023 - Eur Respiratory Soc
This expert group consensus statement emphasises the need for standardising the definition
of progressive fibrosing interstitial lung diseases (F-ILDs), with an accurate initial diagnosis …

[HTML][HTML] Pirfenidone safety and adverse event management in idiopathic pulmonary fibrosis

LH Lancaster, JA de Andrade, JD Zibrak… - European respiratory …, 2017 - Eur Respiratory Soc
Pirfenidone is one of two approved therapies for the treatment of idiopathic pulmonary
fibrosis (IPF). Randomised controlled clinical trials and subsequent post hoc analyses have …

Molecular mechanisms of pulmonary fibrogenesis and its progression to lung cancer: a review

T Kinoshita, T Goto - International journal of molecular sciences, 2019 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive
fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, and …

Lung cancer in patients with idiopathic pulmonary fibrosis

T Karampitsakos, V Tzilas, R Tringidou… - Pulmonary …, 2017 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease of unknown etiology.
With a gradually increasing worldwide prevalence and a mortality rate exceeding that of …

[HTML][HTML] Lung cancer and interstitial lung disease: a literature review

JM Naccache, Q Gibiot, I Monnet… - Journal of thoracic …, 2018 - ncbi.nlm.nih.gov
The association between lung cancer (LC) and interstitial lung disease (ILD) can be
explained by the shared risk factors like smoking and physiopathology of fibrogenesis and …

[HTML][HTML] Acute exacerbations of progressive-fibrosing interstitial lung diseases

M Kolb, B Bondue, A Pesci, Y Miyazaki… - European …, 2018 - Eur Respiratory Soc
Acute exacerbation of interstitial lung disease (ILD) is associated with a poor prognosis and
high mortality. Numerous studies have documented acute exacerbation in idiopathic …

Common pathogenic mechanisms between idiopathic pulmonary fibrosis and lung cancer

A Tzouvelekis, G Gomatou, E Bouros, R Trigidou… - Chest, 2019 - Elsevier
Abundant epidemiologic evidence supports an association between idiopathic pulmonary
fibrosis (IPF) and lung cancer. Lung tumors in patients with IPF develop preferentially in the …

Lung cancer in patients with idiopathic pulmonary fibrosis: a retrospective multicentre study in Europe

T Karampitsakos, P Spagnolo, N Mogulkoc… - …, 2023 - Wiley Online Library
Abstract Background and Objective There remains a paucity of large databases for patients
with idiopathic pulmonary fibrosis (IPF) and lung cancer. We aimed to create a European …