Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease
A Chadt, H Al-Hasani - Pflügers Archiv-European Journal of Physiology, 2020 - Springer
A family of facilitative glucose transporters (GLUTs) is involved in regulating tissue-specific
glucose uptake and metabolism in the liver, skeletal muscle, and adipose tissue to ensure …
glucose uptake and metabolism in the liver, skeletal muscle, and adipose tissue to ensure …
Mammographic breast density as an intermediate phenotype for breast cancer
The amount of radiologically dense breast-tissue appearing on a mammogram varies
between women because of differences in the composition of breast tissue, and is referred …
between women because of differences in the composition of breast tissue, and is referred …
A genome-wide association study identifies novel risk loci for type 2 diabetes
Type 2 diabetes mellitus results from the interaction of environmental factors with a
combination of genetic variants, most of which were hitherto unknown. A systematic search …
combination of genetic variants, most of which were hitherto unknown. A systematic search …
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
W Farris, S Mansourian, Y Chang… - Proceedings of the …, 2003 - National Acad Sciences
Two substrates of insulin-degrading enzyme (IDE), amyloid β-protein (Aβ) and insulin, are
critically important in the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes …
critically important in the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes …
Obesity genetics in mouse and human: back and forth, and back again
Obesity is a major public health concern. This condition results from a constant and complex
interplay between predisposing genes and environmental stimuli. Current attempts to …
interplay between predisposing genes and environmental stimuli. Current attempts to …
Family history of diabetes as a potential public health tool
TA Harrison, LA Hindorff, H Kim, RCM Wines… - American journal of …, 2003 - Elsevier
Given the substantial morbidity and mortality associated with type 2 diabetes, it is important
that public health seek ways to delay or prevent the onset of this condition. Risk factors for …
that public health seek ways to delay or prevent the onset of this condition. Risk factors for …
Genome-wide associations of gene expression variation in humans
The exploration of quantitative variation in human populations has become one of the major
priorities for medical genetics. The successful identification of variants that contribute to …
priorities for medical genetics. The successful identification of variants that contribute to …
Genomewide scans of complex human diseases: true linkage is hard to find
J Altmüller, LJ Palmer, G Fischer, H Scherb… - The American Journal of …, 2001 - cell.com
Many" complex" human diseases, which involve multiple genetic and environmental
determinants, have increased in incidence during the past 2 decades. During the same time …
determinants, have increased in incidence during the past 2 decades. During the same time …
[HTML][HTML] Hepatic expression and cellular distribution of the glucose transporter family
Glucose and other carbohydrates are transported into cells using members of a family of
integral membrane glucose transporter (GLUT) molecules. To date 14 members of this …
integral membrane glucose transporter (GLUT) molecules. To date 14 members of this …
Use of population isolates for mapping complex traits
Geneticists have repeatedly turned to population isolates for mapping and cloning
Mendelian disease genes. Population isolates possess many advantages in this regard …
Mendelian disease genes. Population isolates possess many advantages in this regard …