Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …

Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular
organization, organelle trafficking and chromosome segregation. Microtubule growth and …

Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …

Dynamic instability, the stochastic switching between growth and shrinkage, is essential for
microtubule function. This behavior is driven by GTP hydrolysis in the microtubule lattice and …

At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …

Directed cell migration is critical for embryogenesis and organ development, wound healing
and the immune response. Microtubules are dynamic polymers that control directional …

Microtubule (MT) dynamic instability is driven by GTP hydrolysis and regulated by
microtubule-associated proteins, including the plus-end tracking end-binding protein (EB) …

INTRODUCTION The microtubule cytoskeleton is continuously sculpted by polymerization,
depolymerization, cross-linking, and microtubule severing. Microtubule severing generates …

Small molecules that interfere with microtubule dynamics, such as Taxol and the Vinca
alkaloids, are widely used in cell biology research and as clinical anticancer drugs …

The growth and migration of neurons require continuous remodelling of the neuronal
cytoskeleton, providing a versatile cellular framework for force generation and guided …