Abstract The BMP/TGFβ-Smad, Notch and VEGF signaling guides formation of endothelial
tip and stalk cells. However, the crosstalk of bone morphogenetic proteins (BMPs) and …

Intrauterine growth restriction (IUGR) is a pregnancy specific disease characterized by
decreased growth rate of fetus than the normal growth potential at particular gestational age …

Cancer vaccines have great potential in the fight against metastatic malignancies. Current
anti-tumor immunotherapy is hindered by existing tolerance to tumor-associated antigens …

Background Ubiquitously expressed CTCF is involved in numerous cellular functions, such
as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is normally only …

Melanoma is among the most aggressive cancers due to its tendency to metastasize early.
Phenotype switching between a proliferative and an invasive state has been suggested as a …

Background Pervasive usage of alternative promoters leads to the deregulation of gene
expression in carcinogenesis and may drive the emergence of new genes in …

Abstract As Douglas Hanahan and Robert Weinberg compiled, there are nine hallmarks of
cancer that are conducive to cancer cell development and survival. Previous studies showed …

Present chemotherapeutic drugs have limited efficacy and severe side effects. Considering
the complexity of cancer, an effective strategy is necessary to discover multiple new drug …

CTCFL is expressed in testis, oocytes and embryonic stem cells, and is aberrantly
expressed in malignant cells, and is classified as a cancer-testis gene. We have previously …

印记位点调节物兄弟因子BORIS, 在脊椎动物的进化过程中从羊膜动物开始出现.
人正常生理状态下, 该蛋白仅在男性睾丸中高表达. 雄性小鼠中BORIS 的表达时序与精子发生 …