Clinical pharmacokinetics and pharmacodynamics of propofol
MM Sahinovic, MMRF Struys, AR Absalom - Clinical pharmacokinetics, 2018 - Springer
Propofol is an intravenous hypnotic drug that is used for induction and maintenance of
sedation and general anaesthesia. It exerts its effects through potentiation of the inhibitory …
sedation and general anaesthesia. It exerts its effects through potentiation of the inhibitory …
The experimental and clinical pharmacology of propofol, an anesthetic agent with neuroprotective properties
Y Kotani, M Shimazawa, S Yoshimura… - CNS neuroscience & …, 2008 - Wiley Online Library
Propofol (2, 6‐diisopropylphenol) is a versatile, short‐acting, intravenous (iv) sedative‐
hypnotic agent initially marketed as an anesthetic, and now also widely used for the …
hypnotic agent initially marketed as an anesthetic, and now also widely used for the …
Propofol: a review of its non-anaesthetic effects
I Vasileiou, T Xanthos, E Koudouna, D Perrea… - European journal of …, 2009 - Elsevier
Propofol, a short-acting intravenous anaesthetic agent has gained wide acceptance since its
introduction in the late 80s, not only in operating rooms but also in other departments, due to …
introduction in the late 80s, not only in operating rooms but also in other departments, due to …
The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index
IA Iselin-Chaves, R Flaishon, PS Sebel… - Anesthesia & …, 1998 - journals.lww.com
Abstract The Bispectral Index (BIS) correlates well with the level of consciousness with
single anesthetic drugs. We studied the effect of the interaction of propofol with alfentanil on …
single anesthetic drugs. We studied the effect of the interaction of propofol with alfentanil on …
The pharmacodynamic interaction of propofol and alfentanil during lower abdominal surgery in women.
J Vuyk, T Lim, FH Engbers, AG Burm, AA Vletter… - …, 1995 - europepmc.org
Background Propofol and alfentanil are frequently combined to provide general anesthesia.
The purpose of this study was to characterize the pharmacodynamic interaction between …
The purpose of this study was to characterize the pharmacodynamic interaction between …
Anesthesia matters: patients anesthetized with propofol have less postoperative pain than those anesthetized with isoflurane
SS Cheng, J Yeh, P Flood - Anesthesia & Analgesia, 2008 - journals.lww.com
BACKGROUND: Preclinical studies have suggested that some volatile anesthetics induce a
hyperalgesic state that may be secondary to nicotinic inhibition. A previous trial of treatment …
hyperalgesic state that may be secondary to nicotinic inhibition. A previous trial of treatment …
Analgesic and antihyperalgesic properties of propofol in a human pain model.
O Bandschapp, J Filitz, H Ihmsen, A Berset… - …, 2010 - europepmc.org
Background Propofol (Disoprivan, AstraZeneca AG, Zug, Switzerland) has long been
considered to be nonanalgesic. However, accumulating evidence shows that propofol …
considered to be nonanalgesic. However, accumulating evidence shows that propofol …
Intravenous propofol: unique effectiveness in treating intractable migraine
JC Krusz, V Scott, J Belanger - … : The Journal of Head and Face …, 2000 - Wiley Online Library
Objective.–To report the unique effectiveness of propofol, an intravenous anesthetic agent,
in treating refractory migraines and other headaches in the setting of an outpatient …
in treating refractory migraines and other headaches in the setting of an outpatient …
Anesthetic actions within the spinal cord: contributions to the state of general anesthesia
JG Collins, JJ Kendig, P Mason - Trends in neurosciences, 1995 - Elsevier
The behavioral state known as general anesthesia is the result of actions of general
anesthetic agents at multiple sites within the neuraxis. The most common end point used to …
anesthetic agents at multiple sites within the neuraxis. The most common end point used to …
[PDF][PDF] Dose-dependent effects of propofol on the central processing of thermal pain
RK Hofbauer, P Fiset, G Plourde, SB Backman… - …, 2004 - academia.edu
Background: Anatomic and physiologic data show that mul-tiple regions of the forebrain are
activated by pain. However, the effect of anesthetic level on nociceptive input to these …
activated by pain. However, the effect of anesthetic level on nociceptive input to these …