[HTML][HTML] Molecular Mechanism of Helicobacter pylori-Induced Gastric Cancer

M Alipour - Journal of gastrointestinal cancer, 2021 - Springer
Introduction Various types of cancers threaten human life. The role of bacteria in causing
cancer is controversial, but it has been determined that the Helicobacter pylori infection is …

Type IV secretion in Gram‐negative and Gram‐positive bacteria

E Grohmann, PJ Christie, G Waksman… - Molecular …, 2018 - Wiley Online Library
Type IV secretion systems (T4SSs) are versatile multiprotein nanomachines spanning the
entire cell envelope in Gram‐negative and Gram‐positive bacteria. They play important …

[HTML][HTML] Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis

A Takahashi-Kanemitsu, CT Knight… - Cellular & molecular …, 2020 - nature.com
Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for
gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via the …

[HTML][HTML] Helicobacter pylori CagA and gastric cancer: a paradigm for hit-and-run carcinogenesis

M Hatakeyama - Cell host & microbe, 2014 - cell.com
Helicobacter pylori is a gastric bacterial pathogen that is etiologically linked to human gastric
cancer. The cytotoxin-associated gene A (CagA) protein of H. pylori, which is delivered into …

[HTML][HTML] Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis

S Imai, T Ooki, N Murata-Kamiya, D Komura… - Cell Host & Microbe, 2021 - cell.com
Summary Infection with CagA-producing Helicobacter pylori plays a causative role in the
development of gastric cancer. Upon delivery into gastric epithelial cells, CagA deregulates …

Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer

M Hatakeyama - Proceedings of the Japan Academy, Series B, 2017 - jstage.jst.go.jp
Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor of
gastric cancer. The cagA gene-encoded CagA protein is delivered into gastric epithelial …

Mechanisms of disease: Helicobacter pylori virulence factors

Y Yamaoka - Nature reviews Gastroenterology & hepatology, 2010 - nature.com
Helicobacter pylori plays an essential role in the development of various gastroduodenal
diseases; however, only a small proportion of people infected with H. pylori develop these …

Cargo recognition in clathrin-mediated endocytosis

LM Traub, JS Bonifacino - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
The endosomal system is expansive and complex, characterized by swift morphological
transitions, dynamic remodeling of membrane constituents, and intracellular positioning …

Decoding signalling networks by mass spectrometry-based proteomics

C Choudhary, M Mann - Nature reviews Molecular cell biology, 2010 - nature.com
Signalling networks regulate essentially all of the biology of cells and organisms in normal
and disease states. Signalling is often studied using antibody-based techniques such as …

Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements

ARC Wong, JS Pearson, MD Bright… - Molecular …, 2011 - Wiley Online Library
The human pathogens enteropathogenic and enterohemorrhagic Escherichia coli (EPEC
and EHEC) share a unique mechanism of colonization that results from the concerted action …