Importance of the field: Vascular delivery of several classes of therapeutic agents may
benefit from carriage by red blood cells (RBC), for example, drugs that require delivery into …

The complement system has developed a remarkably simple but elegant manner of
regulating itself. It has faced and successfully dealt with how to facilitate activation on a …

The shortage of available organs remains the greatest barrier to expanding access to
transplant. Despite advances in genetic editing and immunosuppression, survival in …

The possible use of pig organs and tissues as xenografts in humans is actively being
considered in biomedical research. We therefore examined whether pig endogenous …

Success of transplantation as a therapeutic option in terminal organ failure has resulted in
the widespread diffusion of this life-saving treatmet and a consequent worldwide organ …

Since the introduction of organ transplantation into medical practice, progress and optimism
have been abundant. Improvements in immunosuppressive drugs and ancillary care have …

CD97 is an activation-induced antigen on leukocytes with a seven-span transmembrane (7-
TM) region homologous to the secretin receptor superfamily. However, in contrast to this …

The immunologic barriers to successful xenotransplantation are related to the presence of
natural anti‐pig antibodies in humans and non‐human primates that bind to antigens …

Transgenic pigs are promising donor organisms for xenotransplantation as they share many
anatomical and physiological characteristics with humans. The most profound barrier to pig …

Activation of the complement system plays a key role in normal inflammatory response to
injury but may cause substantial injury when activated inappropriately. The cytolytic …