Syndecans are a small family of four transmembrane proteoglycans in mammals. They have
similar structural organization, consisting of an N‐terminal ectodomain, single …

Simple Summary Angiogenesis belongs to the most clinical characteristics of colorectal
cancer (CRC) and is strongly linked to the activation of Wnt/β-catenin signaling. The most …

Abstract Sphingosine-1-phosphate (S1P) induces epithelial–mesenchymal transition (EMT)
in hepatocellular carcinoma (HCC). However, its underlying mechanism remains largely …

Colorectal tumors have been classified based on histologic factors, genetic factors, and
consensus molecular subtypes, all of which affect the tumor microenvironment. Elements of …

The epithelial to mesenchymal transition (EMT) program is a crucial component in the
processes of morphogenesis and embryonic development. The transition of epithelial to …

Syndecans are important mediators of signalling by transmitting external stimuli into the
cells. This role in signal transduction has been attributed mainly to the membrane‐bound …

The tumour microenvironment (TME) includes a variety of non-neoplastic cells and non-
cellular elements such as cytokines, growth factors and enzymes surrounding tumour cells …

Abstract Background Syndecan-1 (SDC-1) is a crucial membrane proteoglycan, which is
confirmed to participate in several tumor cell biological processes. However, the biological …

MicroRNAs (miRs) play critical roles in cancer development, proliferation, epithelial-
mesenchymal transition (EMT), invasion, and migration through regulating the expression of …

Epithelial-mesenchymal transition (EMT) is known to be associated with cancer progression,
metastatic spread, and therapeutic resistance and to occur at the invasive front. Cancer stem …