Neurodevelopmental disorders such as fragile X syndrome (FXS) result in lifelong cognitive
and behavioural deficits and represent a major public health burden. FXS is the most …

The hippocampus and its associated cortical regions in the medial temporal lobe play
essential roles when animals form a cognitive map and use it to achieve their goals. As the …

The prefrontal cortex makes up almost a quarter of the human brain, and it expanded
dramatically during primate evolution. The Neurobiology of the Prefrontal Cortex presents a …

An increasingly popular method of assessing cognitive functions in rodents is the automated
touchscreen platform, on which a number of different cognitive tests can be run in a manner …

This protocol details a subset of assays developed within the touchscreen platform to
measure various aspects of executive function in rodents. Three main procedures are …

We describe a touchscreen method that satisfies a proposed 'wish-list'of desirables for a
cognitive testing method for assessing rodent models of schizophrenia. A number of tests …

The automated touchscreen operant chamber for rats and mice allows for the assessment of
multiple cognitive domains within the same testing environment. This protocol presents the …

Executive function allows us to interact with the world in a purposive, goal-directed manner.
It relies on several cognitive control operations that are mediated by different regions of the …

The response of the human body to multiple spaceflight stressors is complex, but mounting
evidence implicate risks to CNS functionality as significant, able to threaten metrics of …

Background Recent advances in understanding molecular and synaptic mechanisms of
intellectual disabilities (ID) in fragile X syndrome (FXS) and Down syndrome (DS) through …