The striking clinical benefit of PTH in osteoporosis began a new era of skeletal anabolic
agents. Several studies have been performed, new studies are emerging out and yet …

Parathyroid hormone (PTH) is a key regulator of skeletal physiology and calcium and
phosphate homeostasis. It acts on bone and kidney to stimulate bone turnover, increase the …

A novel class of photoreceptors, the intrinsically photosensitive retinal ganglion cells
(ipRGCs), express the photopigment melanopsin and drive non‐image‐forming responses …

Teriparatide and abaloparatide are parathyroid hormone receptor 1 (PTHR1) analogs with
unexplained differential efficacy for the treatment of osteoporosis. Therefore, we compared …

Adipose tissue is one of the tissues in the human body that is renewed during the whole life.
Dysregulation of this process leads to conditions such as obesity, metabolic syndrome, and …

Protein kinase A (PKA) regulates osteoblast cell function in vitro and is activated by
important bone mass modulating agents. We determined whether PKA activation in …

To maintain an optimal body content of phosphorus throughout postnatal life, variable
phosphate absorption from food must be finely matched with urinary excretion. This amazing …

Endocannabinoids (eCBs) are involved in a myriad of physiological processes that are
mediated through the activation of cannabinoid receptors, which are ubiquitously distributed …

Parathyroid hormone (PTH) is the major hormone regulating bone remodeling. Binding of
PTH to the PTH1 receptor (PTH1R), a heterotrimeric G protein coupled receptor (GPCR) …

Activation of G protein-coupled receptors by agonists leads to receptor phosphorylation,
internalization of ligand receptor complexes, and desensitization of hormonal response. The …