Kidney diseases with kidney failure or damage, such as chronic kidney disease (CKD) and
acute kidney injury (AKI), are common clinical problems worldwide and have rapidly …

Herbal medicines (HMs) have long been considered safe and effective without serious toxic
and side effects. With the continuous use of HMs, more and more attention has been paid to …

Abstract Background Aristolochic acids (AAs), a class of carcinogenic and mutagenic natural
products from Aristolochia and Asarum plants, are well-known to be responsible for inducing …

Scientific risk assessment of exogenous and endogenous toxic substances in traditional
Chinese medicine (TCM) is of great significance. The present review comprises a …

Abstract Aristolochic Acid I (AAI) is widely present in traditional Chinese medicines derived
from the Aristolochia genus and is known to cause significant damage to renal tubular …

Cordyceps sinensis (CS) has been widely used as a dietary supplement or traditional
medicine for the prevention, treatment, and prognostication of various diseases, because of …

Background: Nephrotoxicity of drugs contributes to acute kidney injury with high mortality
and morbidity, which crucially limits the application and development of drugs. Although …

Arsenic (As) is a heavy metal known for its detrimental effects on the kidneys, but the precise
mechanisms underlying its toxicity remain unclear. In this study, we employed an integrated …

Celastrol (Cel), derived from the traditional herb Tripterygium wilfordii Hook. f., has anti-
inflammatory, anti-tumor, and immunoregulatory activities. Renal dysfunction, including …

Neurotoxicity studies caused by exposure to acrylamide (AA) are of wide interest, but the
methods for direct analysis of AA targets in living neuronal cells by cysteine profiling are still …