The evolutionarily conserved p53 protein and its cellular pathways mediate tumour
suppression through an informed, regulated and integrated set of responses to …

TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …

Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Inactivation of the transcription factor p53, through either direct mutation or aberrations in
one of its many regulatory pathways, is a hallmark of virtually every tumor. In recent years …

The fundamental biological importance of the Tp53 gene family is highlighted by its
evolutionary conservation for more than one billion years dating back to the earliest …

Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways
is often the result of genetic alterations in critical components in these pathways or upstream …

Thirty years of research on the p53 family of genes has generated almost fifty thousand
publications. The first of these papers detected the p53 protein associated with a viral …

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …

It is poorly understood how a single protein, p53, can be responsive to so many stress
signals and orchestrates very diverse cell responses to maintain/restore cell/tissue functions …

A common ancestor to the three p53 family members of human genes p53, p63, and p73 is
first detected in the evolution of modern‐day sea anemones, in which both structurally and …