Transcriptome profiling in human diseases: new advances and perspectives
In the last decades, transcriptome profiling has been one of the most utilized approaches to
investigate human diseases at the molecular level. Through expression studies, many …
investigate human diseases at the molecular level. Through expression studies, many …
The role of thyroglobulin in thyroid hormonogenesis
CE Citterio, HM Targovnik, P Arvan - Nature Reviews Endocrinology, 2019 - nature.com
In humans, the thyroid hormones T3 and T4 are synthesized in the thyroid gland in a
process that crucially involves the iodoglycoprotein thyroglobulin. The overall structure of …
process that crucially involves the iodoglycoprotein thyroglobulin. The overall structure of …
Integrative analysis of genomic and transcriptomic characteristics associated with progression of aggressive thyroid cancer
Anaplastic thyroid cancer (ATC) and advanced differentiated thyroid cancers (DTCs) show
fatal outcomes, unlike DTCs. Here, we demonstrate mutational landscape of 27 ATCs and …
fatal outcomes, unlike DTCs. Here, we demonstrate mutational landscape of 27 ATCs and …
Comprehensive analysis of the transcriptional and mutational landscape of follicular and papillary thyroid cancers
Follicular thyroid carcinoma (FTC) and benign follicular adenoma (FA) are indistinguishable
by preoperative diagnosis due to their similar histological features. Here we report the first …
by preoperative diagnosis due to their similar histological features. Here we report the first …
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer
Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To
better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis …
better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis …
[HTML][HTML] Poorly differentiated thyroid carcinoma of childhood and adolescence: a distinct entity characterized by DICER1 mutations
Poorly differentiated thyroid carcinomas (PDTC) in young individuals are rare and their
clinical and histopathologic features, genetic mechanisms, and outcomes remain largely …
clinical and histopathologic features, genetic mechanisms, and outcomes remain largely …
[HTML][HTML] Generation and differentiation of adult tissue-derived human thyroid organoids
VML Ogundipe, AH Groen, N Hosper, PWK Nagle… - Stem Cell Reports, 2021 - cell.com
Total thyroidectomy as part of thyroid cancer treatment results in hypothyroidism requiring
lifelong daily thyroid hormone replacement. Unbalanced hormone levels result in persistent …
lifelong daily thyroid hormone replacement. Unbalanced hormone levels result in persistent …
Inflammatory cytokine-regulated LNCPTCTS suppresses thyroid cancer progression via enhancing Snail nuclear export
C Ma, N Zhang, T Wang, H Guan, Y Huang, L Huang… - Cancer Letters, 2023 - Elsevier
Lymph node metastases are commonly observed in diverse malignancies where they
promote cancer progression and poor outcomes, although the molecular basis is …
promote cancer progression and poor outcomes, although the molecular basis is …
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
RBTM Sterenborg, I Steinbrenner, Y Li… - Nature …, 2024 - nature.com
To date only a fraction of the genetic footprint of thyroid function has been clarified. We
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …
PPARγΔ5, a naturally occurring dominant-negative splice isoform, impairs PPARγ function and adipocyte differentiation
Peroxisome-proliferator-activated receptor γ (PPARγ) regulates glucose and lipid
homeostasis, insulin signaling, and adipocyte differentiation. Here, we report the skipping of …
homeostasis, insulin signaling, and adipocyte differentiation. Here, we report the skipping of …