Pd-catalyzed amination reaction of aryl halides has attracted much attention in recent years.
This review underscores selected important recent developments in the catalysis of one of …

Over the years, researchers in drug discovery have taken advantage of the use of privileged
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …

A comprehensive guide to privileged structures and their application in the discovery of new
drugs The use of privileged structures is a viable strategy in the discovery of new medicines …

Sleep is a crucial biological process that is regulated through complex interactions between
multiple brain regions and neuromodulators. As sleep disorders can have deleterious …

Mice overexpressing CB2r (CB2xP) were exposed to open field (OF), light–dark box (LDB)
and elevated plus maze (EPM) tests. Corticotropin-releasing factor (CRF) and pro …

Public concern on mental health has noticeably increased given the high prevalence of
neuropsychiatric disorders. Cognition and emotionality are the most affected functions in …

The first report demonstrating the therapeutic efficacy of an orally applied neurokinin-1
(NK1) receptor antagonist in depression was published 10 years ago. Although there were …

Benzodiazepines have been used clinically for more than 50 years to treat disorders such as
insomnia, anxiety, and epilepsy, as well as to aid muscle relaxation and anesthesia. The …

The fast inhibitory actions of γ-aminobutyric acid (GABA) are mainly mediated by GABAA
receptors (GABAARs) in the brain. The existence of multiple ligand-binding sites and a lack …

Novel N, N-disubstituted indol-3-ylglyoxylamides (1− 56), bearing different combinations of
substituents R1− R5, were synthesized and evaluated as ligands of the translocator protein …