Reproduction in mammals is an extremely energy-intensive process and is therefore tightly
controlled by the body's energy status. Changes in the nutritional status of the body cause …

Ovarian estradiol and leptin are important modulators of whole-body energy homeostasis
that act in the hypothalamus. In a recent paper in Cell Metabolism, González-García et al …

Here, we demonstrate that hypothalamic astrocytic BMAL1 computes cyclic metabolic
information to optimize energetic resources in a sexually dimorphic manner. Knockdown of …

Neuropeptide Y (Npy) is an abundant neuropeptide expressed in the central and peripheral
nervous systems. NPY-secreting neurons in the hypothalamic arcuate nucleus regulate …

Abstract Pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the
hypothalamus (ARC) are considered a major site of leptin action. Due to increasing …

Estrogen receptor alpha (ERα) plays a crucial role in reproductive function in both sexes. It
also mediates cellular responses to estrogens in multiple nonreproductive organ systems …

Background Eccrine sweat gland (SG) plays a crucial role in thermoregulation but exhibits
very limited regenerative potential. Although SG lineage-restricted niches dominate SG …

Abstract Zinc-alpha2-glycoprotein (AZGP1) has been implicated in peripheral metabolism;
however, its role in regulating energy metabolism in the brain, particularly in POMC neurons …

Extensive research is undertaken in rodents to determine the mechanism underlying obesity‐
induced leptin resistance. While body weight is generally tightly controlled in these studies …

Background Today, modern lifestyles and disrupted sleep patterns cause circadian clock
rhythm impairments that are associated with altered leptin levels, which subsequently affect …