Metabolomics as an emerging approach for deciphering the biological impact and toxicity of food contaminants: The case of mycotoxins

P Mandal, O Lanaridi, B Warth… - Critical Reviews in Food …, 2023 - Taylor & Francis
Exposure to mycotoxins through the dietary route occurs on a daily basis while their
deleterious effects are exhibited in the form of ailments, such as inflammation, cancer, and …

Insights into the intestinal toxicity of foodborne mycotoxins through gut microbiota: A comprehensive review

H Ruan, Y Huang, B Yue, Y Zhang, J Lv… - … Reviews in Food …, 2023 - Wiley Online Library
Mycotoxins, which are fungal metabolites, pose a significant global food safety concern by
extensively contaminating food and feed, thereby seriously threatening public health and …

[HTML][HTML] Changes in intestinal barrier functions and gut microbiota in rats exposed to zearalenone

W Zhang, S Zhang, J Wang, A Shan, L Xu - … and Environmental Safety, 2020 - Elsevier
Zearalenone (ZEN) is a mycotoxin that causes serious health problems in humans and
animals. However, few studies have focused on the destruction of the intestinal barrier …

[HTML][HTML] Dietary silymarin supplementation alleviates zearalenone-induced hepatotoxicity and reproductive toxicity in rats

X Gao, ZH Xiao, M Liu, NY Zhang, MM Khalil… - The Journal of …, 2018 - Elsevier
Background Zearalenone (ZEN) can cause serious defects in development and
reproduction in humans and animals. Silymarin shows antioxidant and estrogenic effects …

Label-free electrochemical immunosensor based on biocompatible nanoporous Fe 3 O 4 and biotin–streptavidin system for sensitive detection of zearalenone

Y Wang, G Zhao, H Wang, Y Zhang, N Zhang, D Wei… - Analyst, 2020 - pubs.rsc.org
In this study, a sensitive label-free electrochemical immunosensor was designed based on
nanoporous Fe3O4 and a biotin–streptavidin system to specifically detect zearalenone …

Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression

I Taranu, C Braicu, DE Marin, GC Pistol, M Motiu… - Toxicology Letters, 2015 - Elsevier
The gut represents the main route of intoxication with mycotoxins. To evaluate the effect and
the underlying molecular changes that occurred when the intestine is exposed to …

Metabolomics as a tool for drug discovery and personalised medicine. A review

A Mastrangelo, EG Armitage, A García… - Current topics in …, 2014 - ingentaconnect.com
Studying the effects of drugs on the metabolome constitutes a huge part of the metabolomics
discipline. Whether the approach is associated with drug discovery (altered pathways due to …

[HTML][HTML] Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches

EKK Lo, X Wang, PK Lee, HC Wong, JCY Lee… - Computational and …, 2023 - Elsevier
Zearalenone (ZEA), a secondary metabolite of Fusarium fungi found in cereal-based foods,
promotes the growth of colon, breast, and prostate cancer cells in vitro. However, the lack of …

Dietary methionine restriction regulated energy and protein homeostasis by improving thyroid function in high fat diet mice

Y Yang, J Zhang, G Wu, J Sun, Y Wang, H Guo, Y Shi… - Food & function, 2018 - pubs.rsc.org
Methionine-restricted diets (MRD) show an integrated series of beneficial health effects,
including improving insulin sensitivity, limiting fat deposition, and decreasing oxidative …

Zearalenone induced oxidative stress in the jejunum in postweaning gilts through modulation of the Keap1–Nrf2 signaling pathway and relevant genes

Q Cheng, S Jiang, L Huang, J Ge… - Journal of Animal …, 2019 - academic.oup.com
Researches have shown that dietary zearalenone (ZEA) caused oxidative stress in the liver
and reproductive organs of postweaning gilts. However, information on the effects of ZEA on …