Amide bonds occur in over half of target compounds in medicinal chemistry patents, making
amide bond formation the most commonly performed reaction in the pharmaceutical …

The synthesis of the amide bond between an amine and a carboxylic acid is one of the most
significant reactions in industrial pharmaceutical synthesis. Despite the apparent simplicity …

The use of natural catalysts-enzymes-for the transformation of nonnatural man-made
organic compounds is not at all new: they have been used for more than one hundred years …

Introduction The immense potential of enzymes as catalysts in organic synthesis is well
documented. 1" 5 Nevertheless, organic chemists have been reluctant to add enzymes to …

Biocatalysis in nonaqueous media is becoming increasingly important in organic synthesis.
Lipases are the most used enzymes, especially in transesterification reactions. However, in …

To date, most enzyme-based organic syntheses have employed enzymes in the form of a
crude protein extract. The instability andexpense of highly purified proteins has all but …

MPK has been identified as an antiviral lead compound with selective activity against
herpesviruses HSV-1, HSV-2, and human cytomegalovirus (HCMV) with PRso's of 2.9, 0.5 …

The lipase-catalyzed aminolysis of carboxylic esters is a fairly general reaction that has
been performed with a wide range of esters and amines, generally in anhydrous organic …

This comprehensive text presents a critical discussion of the scopes and limitations of
various organic synthetic methodologies that are available for performing asymmetric …

Microwave irradiation can alter the rate of enzymecatalysed reactions, although the role of
any non-thermal factors in such processes is controversial. While the studies in aqueous …