[HTML][HTML] White adipose tissue dysfunction in obesity and aging

M Reyes-Farias, J Fos-Domenech, D Serra… - Biochemical …, 2021 - Elsevier
Both obesity and aging are associated with the development of metabolic diseases such as
type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose …

[HTML][HTML] Adipose tissue: physiology to metabolic dysfunction

AJ Richard, U White, CM Elks, JM Stephens - Endotext [Internet], 2020 - ncbi.nlm.nih.gov
Like the obesity epidemic, our understanding of adipocytes and adipose tissue is
expanding. Just in the past decade, substantial advances have led to new insights into the …

FGF receptors: cancer biology and therapeutics

M Katoh, H Nakagama - Medicinal research reviews, 2014 - Wiley Online Library
Fibroblast growth factors (FGFs) are involved in a variety of cellular processes, such as
stemness, proliferation, anti‐apoptosis, drug resistance, and angiogenesis. Here, FGF …

New insight into dyslipidemia‐induced cellular senescence in atherosclerosis

Q Xiang, F Tian, J Xu, X Du, S Zhang… - Biological Reviews, 2022 - Wiley Online Library
Atherosclerosis, characterized by lipid‐rich plaques in the arterial wall, is an age‐related
disorder and a leading cause of mortality worldwide. However, the specific mechanisms …

[HTML][HTML] Sex dimorphism and depot differences in adipose tissue function

UA White, YD Tchoukalova - … et Biophysica Acta (BBA)-Molecular Basis of …, 2014 - Elsevier
Obesity, characterized by excessive adiposity, is a risk factor for many metabolic
pathologies, such as type 2 diabetes mellitus (T2DM). Numerous studies have shown that …

[HTML][HTML] Adipose tissue plasticity from WAT to BAT and in between

YH Lee, EP Mottillo, JG Granneman - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Adipose tissue plays an essential role in regulating energy balance through its metabolic,
cellular and endocrine functions. Adipose tissue has been historically classified into …

Hedgehog controls hepatic stellate cell fate by regulating metabolism

Y Chen, SS Choi, GA Michelotti, IS Chan… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: The pathogenesis of cirrhosis, a disabling outcome of defective
liver repair, involves deregulated accumulation of myofibroblasts derived from quiescent …

Does metabolically healthy obesity exist?

A Muñoz-Garach, I Cornejo-Pareja, FJ Tinahones - Nutrients, 2016 - mdpi.com
The relationship between obesity and other metabolic diseases have been deeply studied.
However, there are clinical inconsistencies, exceptions to the paradigm of “more fat means …

Wharton's jelly derived mesenchymal stem cells: future of regenerative medicine? Recent findings and clinical significance

I Kalaszczynska, K Ferdyn - BioMed research international, 2015 - Wiley Online Library
Around 5 million annual births in EU and 131 million worldwide give a unique opportunity to
collect lifesaving Wharton's jelly derived mesenchymal stem cells (WJ‐MSC). Evidences that …

Systematic review of patient factors affecting adipose stem cell viability and function: implications for regenerative therapy

J Varghese, M Griffin, A Mosahebi, P Butler - Stem cell research & therapy, 2017 - Springer
Background The applications for fat grafting have increased recently, within both
regenerative and reconstructive surgery. Although fat harvesting, processing and injection …