Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy: thematic review series: biology of lipid rafts
F Mollinedo, C Gajate - Journal of lipid research, 2020 - ASBMB
Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts,
play a critical role in the compartmentalization of signaling pathways. Physical segregation …
play a critical role in the compartmentalization of signaling pathways. Physical segregation …
The lipid basis of cell death and autophagy
Triglycerides, phospholipids, and cholesterol are prominent lipid types that serve diverse
biological functions. These lipids act as vital structural components of cell membranes …
biological functions. These lipids act as vital structural components of cell membranes …
[HTML][HTML] Plasmalogens, platelet-activating factor and beyond–Ether lipids in signaling and neurodegeneration
F Dorninger, S Forss-Petter, I Wimmer, J Berger - Neurobiology of disease, 2020 - Elsevier
Glycerol-based ether lipids including ether phospholipids form a specialized branch of lipids
that in mammals require peroxisomes for their biosynthesis. They are major components of …
that in mammals require peroxisomes for their biosynthesis. They are major components of …
Bioactive ether lipids: Primordial modulators of cellular signaling
N Rangholia, TM Leisner, SP Holly - Metabolites, 2021 - mdpi.com
The primacy of lipids as essential components of cellular membranes is conserved across
taxonomic domains. In addition to this crucial role as a semi-permeable barrier, lipids are …
taxonomic domains. In addition to this crucial role as a semi-permeable barrier, lipids are …
[HTML][HTML] Antitumor activity of alkylphospholipid edelfosine in prostate cancer models and endoplasmic reticulum targeting
ELH Dakir, C Gajate, F Mollinedo - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer
death among men worldwide. While the five-year survival in local and regional prostate …
death among men worldwide. While the five-year survival in local and regional prostate …
CRAC and SK channels: their molecular mechanisms associated with cancer cell development
A Tiffner, V Hopl, I Derler - Cancers, 2022 - mdpi.com
Simple Summary Cell fate is ultimately determined by the precisely coordinated action of the
Ca2+-signaling machinery. During carcinogenesis, Ca2+ signaling is significantly …
Ca2+-signaling machinery. During carcinogenesis, Ca2+ signaling is significantly …
[HTML][HTML] Suppression of metastatic organ colonization and antiangiogenic activity of the orally bioavailable lipid raft-targeted alkylphospholipid edelfosine
V Alonso-Pérez, V Hernández, MA Calzado… - Biomedicine & …, 2024 - Elsevier
Metastasis is the leading cause of cancer mortality. Metastatic cancer is notoriously difficult
to treat, and it accounts for the majority of cancer-related deaths. The ether lipid edelfosine is …
to treat, and it accounts for the majority of cancer-related deaths. The ether lipid edelfosine is …
Lipid metabolism and Calcium signaling in epithelial ovarian cancer
S Kouba, L Ouldamer, C Garcia, D Fontaine… - Cell calcium, 2019 - Elsevier
Epithelial Ovarian cancer (EOC) is the deadliest gynecologic malignancy and represents the
fifth leading cause of all cancer-related deaths in women. The majority of patients are …
fifth leading cause of all cancer-related deaths in women. The majority of patients are …
[HTML][HTML] Mechanisms of induction of tumors by cholesterol and potential therapeutic prospects
Y Xi, Z Yani, M Jing, W Yinhang, H Xiaohui… - Biomedicine & …, 2021 - Elsevier
Increasing evidence suggested that cholesterol is an important integrant of cell membranes,
that plays a key role in tumor progression, immune dysregulation, and pathological changes …
that plays a key role in tumor progression, immune dysregulation, and pathological changes …
Regulating Cholesterol in Tumorigenesis: A Novel Paradigm for Tumor Nanotherapeutics
H Wu, X Wu, M Zhao, J Yan, C Li, Z Zhang… - International Journal …, 2024 - Taylor & Francis
During the past decade,“membrane lipid therapy”, which involves the regulation of the
structure and function of tumor cell plasma membranes, has emerged as a new strategy for …
structure and function of tumor cell plasma membranes, has emerged as a new strategy for …