To elucidate principles operating in native biological systems and to develop novel
biotechnologies, synthetic biology aims to build and integrate synthetic gene circuits within …

The large arrays of cell types in a multicellular organism are defined by their stereotypic size
and/or morphology, and, for cells in vivo, by their anatomic positions. Historically, this identity …

Reprogramming human fibroblasts to induced pluripotent stem cells (iPSCs) is inefficient,
with heterogeneity among transcription factor (TF) trajectories driving divergent cell states …

Cellular reprogramming drives cells from one stable identity to a new cell fate. By generating
a diversity of previously inaccessible cell types from diverse genetic backgrounds, cellular …

The enteric nervous system (ENS), a collection of neural cells contained in the wall of the
gut, is of fundamental importance to gastrointestinal and systemic health. According to the …

The sparse and stochastic nature of reprogramming has obscured our understanding of how
transcription factors drive cells to new identities. To overcome this limit, we developed a …

Cell morphology is faithfully coupled to its identity but the coupling mechanism remains
elusive. Using somatic cell reprogramming into pluripotency as a model system, we show …

the enteric nervous system is critical for normal gastrointestinal (GI) function. It is the largest
and most diverse component of the autonomic nervous system with cells expressing more …

The development and homeostasis of a multicellular organism require fundamental
biological processes like cell proliferation, cell differentiation, cell migration, and controlled …