Chitosan is a natural polymer with acceptable biocompatibility, biodegradability, and
mechanical stability; hence, it has been widely appraised for drug and gene delivery …

Fungal infections cause severe and life-threatening complications especially in
immunocompromised individuals. Antifungals targeting cellular machinery and cell …

Infectious diseases remain significant health concerns worldwide, and resistance is
particularly common in patients with tuberculosis caused by Mycobacterium tuberculosis …

The ratio between the dose of drug required for optimal efficacy and the dose that causes
toxicity is referred to as the therapeutic window. This ratio can be increased by directing the …

The emerging resistance of crop pathogens to fungicides poses a challenge to food security
and compels discovery of new antifungal compounds. Here, we show that mono-alkyl …

The present review summarizes recent publications devoted to aminoglycosides that study
the main types of resistance to antibiotics of this class and the main directions of chemical …

The conjugation of hydrophobic group (s) to the polycationic hydrophilic core of the antibiotic
drugs aminoglycosides (AGs), targeting ribosomal RNA, has led to the development of …

Although aminoglycoside antibiotics are effective against Gram-negative infections, these
drugs often cause irreversible hearing damage. Binding to the decoding site of the …

An alternative in vitro propagation protocol for medical Cannabis sativa L. cultivars for
pharmaceutical industrial use was established. The aim of the protocol was to reduce the …

Amphiphilic aminoglycosides (AAGs) constitute a new class of antibacterial compounds
targeting the bacterial membranes. We have identified the 3′, 6-dinonyl neamine 9 as a …