Cohesin mediates chromatin loop formation across the genome by extruding chromatin
between convergently oriented CTCF-binding elements. Recent studies indicate that …

Adaptive immunity in jawed vertebrates relies on the assembly of antigen receptor genes by
the recombination activating gene 1 (RAG1)–RAG2 (collectively RAG) recombinase in a …

Unwinding the double helix of the DNA molecule is the basis of gene duplication and gene
editing, and the acceleration of this unwinding process is crucial to the rapid detection of …

Domestication of a transposon (a DNA sequence that can change its position in a genome)
to give rise to the RAG1–RAG2 recombinase (RAG) and V (D) J recombination, which …

Lymphocyte development requires ordered assembly and subsequent modifications of the
antigen receptor genes through V (D) J recombination and Immunoglobulin class switch …

RAG1 and RAG2 form a tetramer nuclease to initiate V (D) J recombination in developing T
and B lymphocytes. The RAG1 protein evolves from a transposon ancestor and possesses …

An effective adaptive immune system depends on the ability of developing B and T cells to
generate diverse immunoglobulin (Ig) and T cell receptor repertoires, respectively. Such …

Protein coding genes can contain specific motifs within their nucleotide sequence that
function as a signal for various biological pathways. The presence of such sequence motifs …

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Copy‐out/paste‐in transposition is a major bacterial DNA mobility pathway. It contributes
significantly to the emergence of antibiotic resistance, often by upregulating expression of …