In recent years, the rapid growth of biological data has increased interest in using
bioinformatics to analyze and interpret this data. Proteomics, which studies the structure …

As a main subtype of post-translational modification (PTM), protein lysine acylations (PLAs)
play crucial roles in regulating diverse functions of proteins. With recent advancements in …

Background The pharmaceutical field faces a significant challenge in validating drug target
interactions (DTIs) due to the time and cost involved, leading to only a fraction being …

As one of the most important post-translational modifications (PTM), lysine acetylation
(Kace) plays an important role in various biological activities. Traditional experimental …

Aim To the best of our knowledge, although there are several computational methods for
ac4C locus prediction, the performance of the models they constructed is poor, and the …

Plastic waste has caused a global environmental crisis. Biocatalytic depolymerization
mediated by enzymes has emerged as an efficient and sustainable alternative for plastic …

Results We find that for functional annotation of proteins, as represented by Gene Ontology
(GO) terms, direct fine-tuning of language models on a simple classification loss has an …

Non-classical secreted proteins (NCSPs) refer to a group of proteins that are located in the
extracellular environment despite the absence of signal peptides and motifs. They usually …

The fundamental role of cells in safeguarding the genome's integrity against DNA double‐
strand breaks (DSBs) is crucial for maintaining chromatin homeostasis and the overall …

The Type III secretion effectors (T3SEs) are bacterial proteins synthesized by Gram‐negative
pathogens and delivered into host cells via the Type III secretion system (T3SS). These …