Melanoma is the sixth most frequent malignancy. It represents 1.7% of all cancer cases
worldwide. Many risk factors are associated with melanoma including ultraviolet radiation …

Extracellular communication, in other words, crosstalk between cells, has a pivotal role in
the survival of an organism. This communication occurs by different methods, one of which is …

Melanoma is an aggressive malignancy originating from pigment-producing melanocytes.
The development of targeted therapies (MAPK pathway inhibitors) and immunotherapies …

The current nanomedicines for cancer therapy based on the enhance permeability and
retention (EPR) effect remain insufficient to satisfy the clinical need, and the challenges …

Tumor microenvironment (TME) is the internal environment in which tumor cells survive,
consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non …

Simple Summary Patients with advanced melanoma are often treated with v-raf murine
sarcoma viral oncogene homolog B1 (BRAF) inhibitors. Although these agents prolong life …

Simple Summary Cutaneous melanoma represents the most aggressive form of skin cancer
and its occurrence, development, and progression are based on the accumulation of several …

Background To date, standardising clinical predictive biomarkers for assessing the response
to immunotherapy remains challenging due to variations in personal genetic signatures …

Cutaneous melanoma (CM) represents one of the most metastasizing and drug resistant
solid tumors. CM is characterized by a remarkable metabolic plasticity and an important …

Melanoma is the less common but the most malignant skin cancer. Since the survival rate of
melanoma metastasis is about 10–15%, many different studies have been carried out in …