Isoniazid (INH) is one of the most active compounds used to treat tuberculosis (TB)
worldwide. In addition, INH has been used as a prophylactic drug for individuals with latent …

Knowledge of the molecular genetic basis of resistance to antituberculous agents has
advanced rapidly since we reviewed this topic 3 years ago. Virtually all isolates resistant to …

Oxidative stress, through the production of reactive oxygen species, is a natural
consequence of aerobic metabolism. Escherichia coli has several major regulators activated …

Present knowledge on peroxiredoxins is reviewed with special emphasis on catalytic
principles, specificities and biological function. Peroxiredoxins are low efficiency …

For decades after its introduction, the mechanisms of action of the front‐line antituberculosis
therapeutic agent isoniazid (INH) remained unclear. Recent developments have shown that …

Fatty acid biosynthesis, the first stage in membrane lipid biogenesis, is catalyzed in most
bacteria by a series of small, soluble proteins that are each encoded by a discrete gene (Fig …

Reactive oxygen species (ROS)-mediated oxidative stress and DNA damage have recently
been recognized as contributing to the efficacy of most bactericidal antibiotics, irrespective of …

Although the primary targets of activated isoniazid (INH) are proteins involved in the
biosynthesis of cell wall mycolic acids, clinical resistance is dominated by specific point …

The bacterial two-component signal transduction systems regulate adaptation processes
and are likely to play a role in Mycobacterium tuberculosis physiology and pathogenesis …

Mycobacterium tuberculosis remains a leading infectious cause of morbidity and mortality.
While antibiotic resistance is cited as a potential threat to efforts aimed at controlling the …