Genetics of the patent ductus arteriosus (PDA) and pharmacogenetics of PDA treatment
Patent ductus arteriosus (PDA) is a frequent, complex, and difficult to treat clinical syndrome
among preterm infants in the neonatal intensive care unit. In addition to known clinical risk …
among preterm infants in the neonatal intensive care unit. In addition to known clinical risk …
Clinical implications of genetic variation in carboxylesterase drug metabolism
Introduction: Mammalian carboxylesterase enzymes are a highly conserved metabolic
pathway involved in the metabolism of endogenous and exogenous compounds including …
pathway involved in the metabolism of endogenous and exogenous compounds including …
Sacubitril is selectively activated by carboxylesterase 1 (CES1) in the liver and the activation is affected by CES1 genetic variation
Sacubitril was recently approved by the Food and Drug Administration for use in
combination with valsartan for the treatment of patients with heart failure with reduced …
combination with valsartan for the treatment of patients with heart failure with reduced …
[HTML][HTML] Quantitative proteomic analysis identifies novel regulators of methotrexate resistance in choriocarcinoma
F Jun, Z Peng, Y Zhang, D Shi - Gynecologic Oncology, 2020 - Elsevier
Objective Although methotrexate (MTX) is commonly used for the treatment of
choriocarcinoma, chemoresistance to MTX may occur in a considerable fraction of patients …
choriocarcinoma, chemoresistance to MTX may occur in a considerable fraction of patients …
Sensing carboxylesterase 1 in living systems by a practical and isoform-specific fluorescent probe
L Ding, Z Tian, J Hou, T Dou, Q Jin, D Wang… - Chinese Chemical …, 2019 - Elsevier
Abstract Carboxylesterase 1 (CES1), one of the most abundant serine hydrolases in
mammals, has drawn much attentions in recent years, owing to this enzyme involves in …
mammals, has drawn much attentions in recent years, owing to this enzyme involves in …
Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1, 3-dione scaffold
GF Makhaeva, SV Lushchekina, NP Boltneva… - European Journal of …, 2021 - Elsevier
An expanded series of alkyl 2-arylhydrazinylidene-3-oxo-3-polyfluoroalkylpropionates
(HOPs) 3 was obtained via Cu (OAc) 2-catalyzed azo coupling. All were nanomolar …
(HOPs) 3 was obtained via Cu (OAc) 2-catalyzed azo coupling. All were nanomolar …
Association of oseltamivir activation with gender and carboxylesterase 1 genetic polymorphisms
Oseltamivir, an inactive anti‐influenza virus prodrug, is activated (hydrolysed) in vivo by
carboxylesterase 1 (CES 1) to its active metabolite oseltamivir carboxylate. CES 1 functions …
carboxylesterase 1 (CES 1) to its active metabolite oseltamivir carboxylate. CES 1 functions …
A comprehensive functional assessment of carboxylesterase 1 nonsynonymous polymorphisms
Carboxylesterase 1 (CES1) is the predominant human hepatic hydrolase responsible for the
metabolism of many clinically important medications. CES1 expression and activity vary …
metabolism of many clinically important medications. CES1 expression and activity vary …
Pharmacometabolomics informs about pharmacokinetic profile of methylphenidate
R Kaddurah‐Daouk, T Hankemeier… - CPT …, 2018 - Wiley Online Library
Carboxylesterase 1 (CES1) metabolizes methylphenidate and other drugs. CES1 gene
variation only partially explains pharmacokinetic (PK) variability. Biomarkers predicting the …
variation only partially explains pharmacokinetic (PK) variability. Biomarkers predicting the …
Cannabidiol Inhibits In Vitro Human Liver Microsomal Metabolism of Remdesivir
Introduction: The year 2020 began with the world being flounced with a wave of novel
coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) disease …
coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) disease …