Cardiometabolic risk factors associated with type 2 diabetes mellitus: a mechanistic insight

S Chakraborty, A Verma, R Garg… - Clinical Medicine …, 2023 - journals.sagepub.com
A complex metabolic condition referred to as Type 2 diabetes mellitus (T2DM) is
characterized by insulin resistance (IR) and decreased insulin production. Obesity …

Narcolepsy—A Neuropathological Obscure Sleep Disorder: A Narrative Review of Current Literature

V Chavda, B Chaurasia, GE Umana, SO Tomasi, B Lu… - Brain Sciences, 2022 - mdpi.com
Narcolepsy is a chronic, long-term neurological disorder characterized by a decreased
ability to regulate sleep–wake cycles. Some clinical symptoms enter into differential …

Empagliflozin attenuates transient cerebral ischemia/reperfusion injury in hyperglycemic rats via repressing oxidative–inflammatory–apoptotic pathway

EF Amin, RA Rifaai… - Fundamental & Clinical …, 2020 - Wiley Online Library
Hyperglycemia is one of the ischemic neuronal damage triggers that exacerbate the
response to oxidative stress, inflammation, and apoptosis induced by cerebral …

TOAST Subtypes of Ischemic Stroke and Its Risk Factors: A Hospital‐Based Study at Cipto Mangunkusumo Hospital, Indonesia

S Harris, S Sungkar, A Rasyid… - Stroke research and …, 2018 - Wiley Online Library
Background and Purpose. Stroke is a leading cause of death and disability, with ischemic
stroke as the highest prevalent cases in Indonesia. Ischemic stroke can be classified further …

Receptor for advanced glycation end product, organ crosstalk, and pathomechanism targets for comprehensive molecular therapeutics in diabetic ischemic stroke

NL Rao, GB Kotian, JK Shetty, BP Shelley, MK Dmello… - Biomolecules, 2022 - mdpi.com
Diabetes mellitus, a well-established risk factor for stroke, is related to higher mortality and
poorer outcomes following the stroke event. Advanced glycation end products (AGEs), their …

Formulation and therapeutic evaluation of isoxsuprine-loaded nanoparticles against diabetes-associated stroke

HA Abou-Taleb, BN Aldosari, RM Zaki, O Afzal… - Pharmaceutics, 2023 - mdpi.com
Ischemic stroke is the second-leading cause of death. Hyperglycemia, which is characteristic
of diabetes mellitus, contributes to the development of endothelial dysfunction and increases …

Immune-inflammatory, metabolic, oxidative, and nitrosative stress biomarkers predict acute ischemic stroke and short-term outcome

DF Alfieri, MF Lehmann, T Flauzino… - Neurotoxicity …, 2020 - Springer
Abstract Immune-inflammatory, metabolic, oxidative, and nitrosative stress (IMO&NS)
pathways and, consequently, neurotoxicity are involved in acute ischemic stroke (IS). The …

Non-coding RNAs based molecular links in type 2 diabetes, ischemic stroke, and vascular dementia

M Vijayan, PH Reddy - Journal of Alzheimer's Disease, 2020 - content.iospress.com
This article reviews recent advances in the study of microRNAs (miRNAs), long non-coding
RNAs (lncRNAs), and their functions in type 2 diabetes mellitus (T2DM), ischemic stroke (IS) …

Brain energy metabolism in ischemic stroke: effects of smoking and diabetes

AE Sifat, S Nozohouri, SR Archie… - International Journal of …, 2022 - mdpi.com
Proper regulation of energy metabolism in the brain is crucial for maintaining brain activity in
physiological and different pathophysiological conditions. Ischemic stroke has a complex …

Association of high blood homocysteine and risk of increased severity of ischemic stroke events

S Harris, A Rasyid, M Kurniawan… - … Journal of Angiology, 2019 - thieme-connect.com
Stroke is the leading cause of death and disability in the world as well as in Indonesia. Initial
stroke severity is an important factor that affects short-and long-term stroke outcomes. This …