Proteins are dynamic entities that undergo a plethora of conformational changes that may
take place on a wide range of time scales. These changes can be as small as the rotation of …

▪ Abstract Src family protein tyrosine kinases are activated following engagement of many
different classes of cellular receptors and participate in signaling pathways that control a …

Protein kinases operate in a large number of distinct signaling pathways, where the tight
regulation of their catalytic activity is crucial to the development and maintenance of …

Human immunodeficiency virus type 1 is a complex retrovirus encoding 15 distinct proteins.
Substantial progress has been made toward understanding the function of each protein, and …

The Ras-dependent activation of mitogen-activated protein (MAP) kinase pathways by many
receptors coupled to heterotrimeric guanine nucleotide binding proteins (G proteins) …

▪ Abstract Tyrosine phosphorylation is one of the key covalent modifications that occurs in
multicellular organisms as a result of intercellular communication during embryogenesis and …

A protein semisynthesis method—expressed protein ligation—is described that involves the
chemoselective addition of a peptide to a recombinant protein. This method was used to …

ABSTRACT A common focus among molecular and cellular biologists is the identification of
proteins that interact with each other. Yeast two‐hybrid, cDNA expression library screening …

Signal transduction can be defined as the coordinated relay of messages derived from
extracellular cues to intracellular effectors. More simply put, information received on the cell …

Unregulated activation of Src kinases leads to aberrant signalling, uncontrolled growth and
differentiation of cancerous cells. Reaching a complete mechanistic understanding of large …