Quasi-LD-Targeted and ONOO-Responsive Fluorescent Probe for Investigating the Interaction of Nonalcoholic Fatty Liver with Drug-Induced Liver Injury

N Wang, X Lu, J Wang, H Wang, B Zhang… - Analytical …, 2023 - ACS Publications
Hepatic lipid droplets (LDs) and peroxynitrite (ONOO–) levels are closely related to
nonalcoholic fatty liver disease (NAFLD). Additionally, some drug-induced liver injury (DILI) …

Recent advances in organelle-specific two-photon small-molecule fluorescent probes for bioanalysis in live tissues

HW Lee, V Juvekar, DJ Lee, HM Kim - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Biological events occur in specific cellular organelles to perform specialized roles in cells
and collaborate with other organelles. Various methods have been used to study organelle …

Analytical techniques for single-cell biochemical assays of lipids

M Yao, M Vaithiyanathan… - Annual Review of …, 2023 - annualreviews.org
Lipids are essential cellular components forming membranes, serving as energy reserves,
and acting as chemical messengers. Dysfunction in lipid metabolism and signaling is …

Highly efficient red/NIR-emissive fluorescent probe with polarity-sensitive character for visualizing cellular lipid droplets and determining their polarity

G Peng, J Dai, R Zhou, G Liu, X Liu, X Yan… - Analytical …, 2022 - ACS Publications
Lipid droplets (LDs), which are ubiquitous organelles existing in almost all eukaryotic cells,
have attracted a lot of attention in the field of cell biology over the last decade. For the …

A stable NIR fluorescent probe for imaging lipid droplets in triple-negative breast cancer

H Chen, S Guo, Y Liu, H Jiang, YX Liao, J Shen… - Sensors and Actuators B …, 2024 - Elsevier
Lipid droplets (LDs) are closely associated various diseases, such as liver diseases and
cancers. In the last decade, a mountain of fluorescent probes has been developed for LDs …

Polarity-Driven Two-Photon Fluorescent Probe for Monitoring the Perturbation in Lipid Droplet Levels during Mitochondrial Dysfunction and Acute Pancreatitis

S Biswas, M Baruah, A Shil, S Sarkar, M Ali… - ACS …, 2023 - ACS Publications
Lipid droplets (LDs) act as an energy reservoir in cancer cells; on the other hand,
mitochondria are hyperactive to fulfill the energy demand to accelerate cell proliferation. We …

Engineering of a NIR fluorescent probe for high-fidelity tracking of lipid droplets in living cells and nonalcoholic fatty liver tissues

J Hong, Y Liu, X Tan, G Feng - Biosensors and Bioelectronics, 2023 - Elsevier
LDs (Lipid droplets) are key organelles for lipid metabolism and storage, which are closely
related to ferroptosis and fatty liver. Due to its small size and highly dynamic nature …

Multifunctional Theranostic Probe Based on the Pim-1 Kinase Inhibitor with the Function of Tracking pH Fluctuations during Treatment

C Liu, X Wang, H Zhu, K Wang, M Yu, Y Zhang… - Analytical …, 2023 - ACS Publications
Currently, kinase inhibitors have been applied in the diagnosis or treatment of cancer with
their unique advantages. It is of great significance to develop some comprehensive …

Fluorescence Imaging of Diabetic Cataract-Associated Lipid Droplets in Living Cells and Patient-Derived Tissues

S Guo, C Li, L Lian, Z Le, Y Ren, YX Liao, J Shen… - ACS …, 2023 - ACS Publications
Diabetic cataract (DC) surgery carries risks such as slow wound healing, macular edema,
and progression of retinopathy and is faced with a deficiency of effective drugs. In this …

In Vivo Imaging of Lipid Droplets and Oxygen Status in Hepatic Tissues of Nonalcoholic Fatty Liver Model Mice Using a Lipophilic Ir(III) Complex

K Purevsuren, S Shiozaki, K Mizukami… - Analytical …, 2023 - ACS Publications
Nonalcoholic fatty liver disease (NAFLD) is becoming common worldwide. In
pathophysiological studies of NAFLD, an in vivo optical probe that enables visualization of …