Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Chemical Biology of H2S Signaling through Persulfidation

MR Filipovic, J Zivanovic, B Alvarez… - Chemical …, 2018 - ACS Publications
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

Blood–spinal cord barrier in spinal cord injury: a review

LY Jin, J Li, KF Wang, WW Xia, ZQ Zhu… - Journal of …, 2021 - liebertpub.com
The blood–spinal cord barrier (BSCB), a physical barrier between the blood and spinal cord
parenchyma, prevents the toxins, blood cells, and pathogens from entering the spinal cord …

International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors

C Szabo, A Papapetropoulos - Pharmacological reviews, 2017 - ASPET
Over the last decade, hydrogen sulfide (H2S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …

Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning

G Heusch - Circulation research, 2015 - Am Heart Assoc
Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Gas‐generating nanoplatforms: material chemistry, multifunctionality, and gas therapy

L Yu, P Hu, Y Chen - Advanced Materials, 2018 - Wiley Online Library
The fast advances of theranostic nanomedicine enable the rational design and construction
of diverse functional nanoplatforms for versatile biomedical applications, among which gas …

The protective role of curcumin in myocardial ischemia–reperfusion injury

A Mokhtari‐Zaer, N Marefati, SL Atkin… - Journal of cellular …, 2019 - Wiley Online Library
Coronary artery disease (CAD) is a well‐known pathological condition that is characterized
by high morbidity and mortality. The main pathological manifestation of CAD is myocardial …

The role of hydrogen peroxide in redox-dependent signaling: homeostatic and pathological responses in mammalian cells

N Di Marzo, E Chisci, R Giovannoni - Cells, 2018 - mdpi.com
Hydrogen peroxide (H2O2) is an important metabolite involved in most of the redox
metabolism reactions and processes of the cells. H2O2 is recognized as one of the main …

Physiological implications of hydrogen sulfide: a whiff exploration that blossomed

R Wang - Physiological reviews, 2012 - journals.physiology.org
The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to
plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S …

Nrf2 for cardiac protection: pharmacological options against oxidative stress

QM Chen - Trends in Pharmacological Sciences, 2021 - cell.com
Myocardial ischemia or reperfusion increases the generation of reactive oxygen species
(ROS) from damaged mitochondria, NADPH oxidases, xanthine oxidase, and inflammation …