The important interface between apolipoprotein E and neuroinflammation in Alzheimer's disease
CM Kloske, DM Wilcock - Frontiers in immunology, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disease, currently
affecting over 5 million Americans with projections expected to rise as the population ages …
affecting over 5 million Americans with projections expected to rise as the population ages …
APOE Alleles and Diet in Brain Aging and Alzheimer's Disease
HN Yassine, CE Finch - Frontiers in aging neuroscience, 2020 - frontiersin.org
The APOE gene alleles modify human aging and the response to the diet at many levels
with diverse pleotropic effects from gut to brain. To understand the interactions of APOE …
with diverse pleotropic effects from gut to brain. To understand the interactions of APOE …
The cell biology of APOE in the brain
IA Windham, S Cohen - Trends in Cell Biology, 2023 - cell.com
Apolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE
is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other …
is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other …
Effects of DHA on cognitive dysfunction in aging and Alzheimer's disease: The mediating roles of ApoE
X Zhang, T Yuan, X Chen, X Liu, J Hu, Z Liu - Progress in Lipid Research, 2023 - Elsevier
The prevalence of Alzheimer's disease (AD) continues to rise due to the increasing aging
population. Among the various genetic factors associated with AD, apolipoprotein E (ApoE) …
population. Among the various genetic factors associated with AD, apolipoprotein E (ApoE) …
Cell-specific production, secretion, and function of apolipoprotein E
Apolipoprotein E (apoE) is a 34-kDa glycoprotein that is secreted from many cells
throughout the body. ApoE is best known for its role in lipoprotein metabolism. Recent …
throughout the body. ApoE is best known for its role in lipoprotein metabolism. Recent …
Impact of apolipoprotein E on Alzheimer's disease
PS Hauser, RO Ryan - Current Alzheimer Research, 2013 - ingentaconnect.com
A key feature of Alzheimer's disease (AD) is deposition of extracellular amyloid plaque
comprised chiefly of the amyloid β (Aβ) peptide. Studies of Aβ have shown that it may be …
comprised chiefly of the amyloid β (Aβ) peptide. Studies of Aβ have shown that it may be …
In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis
JD Ulrich, JM Burchett, JL Restivo, DR Schuler… - Molecular …, 2013 - Springer
Background The APOE4 allele variant is the strongest known genetic risk factor for
developing late-onset Alzheimer's disease. The link between apolipoprotein E (apoE) and …
developing late-onset Alzheimer's disease. The link between apolipoprotein E (apoE) and …
High‐density lipoprotein mimetic peptide 4F mitigates amyloid‐β‐induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia
D Chernick, S Ortiz‐Valle, A Jeong… - Journal of …, 2018 - Wiley Online Library
The apolipoprotein E (apoE) ε4 allele is the primary genetic risk factor for late‐onset
Alzheimer's disease (AD). ApoE in the brain is produced primarily by astrocytes; once …
Alzheimer's disease (AD). ApoE in the brain is produced primarily by astrocytes; once …
Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway
apoE is the primary lipid carrier within the CNS and the strongest genetic risk factor for late
onset Alzheimer's disease (AD). apoE is primarily lipidated via ABCA1, and both are under …
onset Alzheimer's disease (AD). apoE is primarily lipidated via ABCA1, and both are under …
Apolipoprotein E isoform-specific effects on lipoprotein receptor processing
Recent findings indicate an isoform-specific role for apolipoprotein E (apoE) in the
elimination of beta-amyloid (Aβ) from the brain. ApoE is closely associated with various …
elimination of beta-amyloid (Aβ) from the brain. ApoE is closely associated with various …