Importance Mortality among people with opioid dependence is higher than that of the
general population. Opioid agonist treatment (OAT) is an effective treatment for opioid …

Background Opioid use disorder (OUD) and mental disorders are major public health issues
and comorbidity is common. Among people with OUD, comorbid mental disorders are …

Childhood trauma is related to substance use disorder; however, few studies have
examined the relationship between childhood trauma and the age at which the drug was first …

A robust body of research has shown that traumatic experiences occurring during critical
developmental periods of childhood when neuronal plasticity is high increase risks for a …

BackgroundElucidation of the interaction of biological and psychosocial/environmental
factors on opioid dependence (OD) risk can inform our understanding of the etiology of OD …

The current opioid use epidemic originates in a long history of opium use, trade, and
criminalization dating back to ancient civilizations. 1 In the United States, opium …

Background There is little study of lifetime trauma exposure among individuals engaged in
medication treatment for opioid use disorder (MOUD). A multisite study provided the …

Rationale Childhood maltreatment (CM) leads to detrimental mental health outcomes, such
as substance use disorders (SUD). This study examined prevalence and severity of all five …

Introduction Opioid analgesic treatment during surgery entails the risk of persistent use.
Experiences of childhood adversity have been shown to increase opioid reward in …

Psychosocial factors predict the incidence and progression of cardiovascular disease
(CVD). There is accumulating evidence for the importance of childhood maltreatment for the …