Leukemia is a hematological malignancy associated with the uncontrolled proliferation of
mutant progenitors, suppressing the production of normal blood cells. Current treatments …

Purpose of review In this review, we emphasize up-to-date practical cytogenetic and
molecular aspects of chronic myeloid leukemia (CML) and summarize current knowledge on …

BCR-ABL-positive acute myeloid leukemia (AML) is a rare subtype of AML that is now
included as a provisional entity in the 2016 revised WHO classification of myeloid …

Acute myeloid leukaemia (AML) is a haematological malignancy characterized by clonal
stem cell proliferation and aberrant block in differentiation. Dysfunction of epigenetic …

Dysregulation of tyrosine kinases (TKs) may play a role in leukemogenesis by promoting
survival and proliferation of acute myeloid leukemia (AML) cells. In AML, the main TKs …

Inhibitors that impact function of kinases are valuable both for the biological research as well
as therapy of kinase-associated diseases, such as different cancers. There are quite a …

Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the
accumulation of immature myeloid progenitor cells in the bone marrow, compromising of …

The Philadelphia chromosome resulting from t (9; 22)(q34; q11. 2) or its variants is a
defining event in chronic myeloid leukemia. It is also observed in several types of de novo …

The aim of the study was to assess the role of allogeneic stem cell transplantation (SCT) in
patients diagnosed with BCR‐ABL1‐positive acute myeloid leukemia (AML). Fifty‐seven …

Breakpoint cluster region-Abelson (BCR-ABL1) chimeric protein and mutated
Nucleophosmin (NPM1) are often present in hematological cancers, but they rarely coexist …