RNA-binding proteins (RBPs) are central actors of RNA post-transcriptional regulation.
Experiments to profile-binding sites of RBPs in vivo are limited to transcripts expressed in …

RNA granules are protein/RNA condensates. How specific mRNAs are recruited to
cytoplasmic RNA granules is not known. Here, we characterize the transcriptome and …

Precursor mRNA (pre-mRNA) splicing is essential for gene expression in most eukaryotic
organisms. Previous studies from mammals, Drosophila, and yeast show that the majority of …

The numerous neurons and glia that form the brain originate from tightly controlled growth
and division of neural stem cells, regulated systemically by important known stem cell …

Interactions between proteins and RNA are at the base of numerous cellular regulatory and
functional phenomena. The investigation of the biological relevance of non-coding RNAs …

Background Post-transcriptional regulation via RNA-binding proteins plays a fundamental
role in every organism, but the regulatory mechanisms lack important understanding …

The TRIM-NHL protein Meiotic P26 (Mei-P26) acts as a regulator of cell fate in Drosophila.
Its activity is critical for ovarian germline stem cell maintenance, differentiation of oocytes …

Motivation Bioinformatics software tools operate largely through the use of specialized
genomics file formats. Often these formats lack formal specification, making it difficult or …

An interplay of experimental and computational methods is required to achieve a
comprehensive understanding of protein-RNA interactions. Crosslinking and …

Circular RNAs (circRNAs) arise from back-splicing of precursor RNAs and accumulate in the
nervous system of animals, where they are thought to regulate gene expression and …