Fracture-related infection

TF Moriarty, WJ Metsemakers, M Morgenstern… - Nature Reviews …, 2022 - nature.com
Musculoskeletal trauma leading to broken and damaged bones and soft tissues can be a life-
threating event. Modern orthopaedic trauma surgery, combined with innovation in medical …

Staphylococcal osteomyelitis: disease progression, treatment challenges, and future directions

N Kavanagh, EJ Ryan, A Widaa, G Sexton… - Clinical microbiology …, 2018 - Am Soc Microbiol
Osteomyelitis is an inflammatory bone disease that is caused by an infecting microorganism
and leads to progressive bone destruction and loss. The most common causative species …

Electroactive biomaterials for facilitating bone defect repair under pathological conditions

BC Heng, Y Bai, X Li, LW Lim, W Li, Z Ge… - Advanced …, 2023 - Wiley Online Library
Bone degeneration associated with various diseases is increasing due to rapid aging,
sedentary lifestyles, and unhealthy diets. Living bone tissue has bioelectric properties critical …

Staphylococcus aureus osteomyelitis: bone, bugs, and surgery

KL Urish, JE Cassat - Infection and immunity, 2020 - Am Soc Microbiol
Osteomyelitis, or inflammation of bone, is most commonly caused by invasion of bacterial
pathogens into the skeleton. Bacterial osteomyelitis is notoriously difficult to treat, in part …

Staphylococcus aureus Evasion of Host Immunity in the Setting of Prosthetic Joint Infection: Biofilm and Beyond

BF Ricciardi, G Muthukrishnan, E Masters… - Current reviews in …, 2018 - Springer
Abstract Purpose of Review The incidence of complications from prosthetic joint infection
(PJI) is increasing, and treatment failure remains high. We review the current literature with a …

[HTML][HTML] Current concepts of osteomyelitis: from pathologic mechanisms to advanced research methods

MI Hofstee, G Muthukrishnan, GJ Atkins, M Riool… - The American journal of …, 2020 - Elsevier
Osteomyelitis is an inflammation of the bone and bone marrow that is most commonly
caused by a Staphylococcus aureus infection. Much of our understanding of the underlying …

Innate immunity to Staphylococcus aureus: evolving paradigms in soft tissue and invasive infections

SL Brandt, NE Putnam, JE Cassat… - The Journal of …, 2018 - journals.aai.org
Staphylococcus aureus causes a wide range of diseases that together embody a significant
public health burden. Aided by metabolic flexibility and a large virulence repertoire, S …

MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis

NE Putnam, LE Fulbright, JM Curry, CA Ford… - PLoS …, 2019 - journals.plos.org
Staphylococcus aureus is able to infect virtually all organ systems and is a frequently
isolated etiologic agent of osteomyelitis, a common and debilitating invasive infection of …

Staphylococcus aureus infects osteoclasts and replicates intracellularly

JL Krauss, PM Roper, A Ballard, CC Shih… - MBio, 2019 - Am Soc Microbiol
Osteomyelitis (OM), or inflammation of bone tissue, occurs most frequently as a result of
bacterial infection and severely perturbs bone structure. OM is predominantly caused by …

Quorum Sensing and Toxin Production in Staphylococcus aureus Osteomyelitis: Pathogenesis and Paradox

CE Butrico, JE Cassat - Toxins, 2020 - mdpi.com
Staphylococcus aureus is a Gram-positive pathogen capable of infecting nearly every
vertebrate organ. Among these tissues, invasive infection of bone (osteomyelitis) is …